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prélèvement PK

English translation: PK sampling

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

French term or phrase:	prélèvement PK
English translation:	PK sampling
Entered by:	Nigel Wheatley

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21:02 Jan 25, 2012

French to English translations [PRO]
Medical - Medical (general) / tests

French term or phrase: prélèvement PK

This appears in a list of tests that will be carried out on patients in a clinical trial for a new drug to treat multiple myeloma. There no other 'context' to speak of, and I can't find anything that matches in the rest of the PIS.

PK can mean "protein kinase", but I can't see how that fits here. All suggestions are welcome!

Nigel Wheatley KudoZ activity Questions: 21 (3 open) Answers: 116 United Kingdom
Local time: 17:20

PK sampling

Explanation:
This could be the EN abbreviation for 'pharmacokinetic' - pharmacocinétique in FR. Additional samplings of blood, urine and possibly other samples are necessary to determine the fate of the drug in the body (absorption, distribution, metabolism, excretion...). It would seem to make sense in the context of a clinical trial for a new drug.

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Note added at 25 mins (2012-01-25 21:27:41 GMT)
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Some references:

http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01359...

http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01445...

Optimal population designs for PK models with serial sampling. http://www.ncbi.nlm.nih.gov/pubmed/15702610

Selected response from:

Isabelle Berquin
Local time: 12:20

Grading comment

Agree, almost a "kick myself" moment ;) Thanks for resolving my inspiration failure
4 KudoZ points were awarded for this answer

Summary of answers provided

3 +7

PK sampling

Isabelle Berquin

pyruvate kinase

Jessie Nelson

typo for BK? sampling/screening for BK

Drmanu49

Summary of reference entries provided

Pharmacokinetics

Sean Sheahan

Answers

10 mins confidence:

typo for BK? sampling/screening for BK

Explanation:
web5.unilim.fr/cr_amylose_al/spip.php?rubrique86
Le plus souvent cette production se fait dans le cadre d'un myélome de stade I ou ..... et qu'elle est susceptible de contaminer les prélèvements faits par cytaphérèse. ...... Arendt BK, Ahmann GJ, Fonseca R, Mulvihill EM, Dispenzieri, A. Sikkink.

www.centres-pharmacovigilance.net/.../bulletin_crpv_fw_N10....
Format de fichier: PDF/Adobe Acrobat
multiple chez les patients non traités inéligibles à la chimiothérapie à haute dose avec ... mofetil, sirolimus : Concernant les néphropathies associées au BK et les .... myélome multiple traité par thalidomide ou lénalidomide en association avec ...

jvi.asm.org/content/84/4/2150.full - Traduire cette page
de E Bernhoff - 2010 - Cité 11 fois - Autres articles
Leflunomide Inhibition of BK Virus Replication in Renal Tubular Epithelial Cells ▿ ..... induces apoptosis and diminishes proliferation of multiple myeloma cells.
Critical Care | Full text | Clinical review: Specific aspects of ...
ccforum.com/content/10/2/211 - Traduire cette page
de M Darmon - 2006 - Cité 26 fois - Autres articles
11 Apr 2006 – Several factors may cause renal failure in myeloma patients, with cast .... The well-documented association between the BK virus and ...

Drmanu49
Local time: 18:20
Specializes in field
Native speaker of:

English,

French
PRO pts in category: 2125

20 mins confidence:

peer agreement (net): +7

PK sampling

Isabelle Berquin
Local time: 12:20
Specializes in field
Native speaker of:

French
PRO pts in category: 48

Grading comment

Agree, almost a "kick myself" moment ;) Thanks for resolving my inspiration failure

Notes to answerer

Asker: Indeed, that would make very good sense, thanks! :)

1 hr confidence:

pyruvate kinase

Explanation:
According to the Dictionary of Medicine of Svetolik P. Djordjević revised edition 2004, PK stands for "pyruvate kinase-Internal Medicine and Laboratory". pg 653.
I tried a Google search for "pyruvate kinase and myeloma". There is a connection, but the articles exceed my ability to understand. You may have better luck.

Jessie Nelson
United States
Local time: 12:20
Specializes in field
Native speaker of:

English

Reference comments

30 mins

Reference: Pharmacokinetics

Reference information:
The reference speaks for itself...

Reference: http://myeloma.org/ArticlePage.action?articleId=3594

Sean Sheahan
France
Specializes in field
Native speaker of:

English

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English translation: PK sampling

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English translation: PK sampling

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