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scheranfällig

English translation: susceptible to shearing

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:scheranfällig
English translation:susceptible to shearing
Entered by: Allan Wier
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04:09 Jul 7, 2003
German to English translations [PRO]
Science - Biology (-tech,-chem,micro-) / biochemistry, genetics
German term or phrase: scheranfällig
I am having difficulty with the term "scheranfällig" in a dissertation on the "Expression of antibody C-DNA in Chinese hamster ovary cells"

"Genomische DNA ist hochmolekular and damit sehr scheranfällig."

Many thanks for any light you can shed on this term

Allan Wier
Allan Wier
United States
Local time: 05:07
susceptible to shearing
Explanation:
Hi Allan,

A bit of a tough one, but I think I have found some good sites which explain what is going on. The Scher- part is short for Scherung, Scherkraft, which is shearing. I found the following (simple) warning in a site:

Hochmolekular => Scherung!

New Protocols for Isolating High- Molecular-Weight Genomic DNA - ... of the DNA —the point in purification methodology where DNA is most ***susceptible to shearing forces***. Fully hydrated high-molecular-weight DNA is ready to use ...
www.stratagene.com/vol12_2/p66-67.htm -
... High molecular weight genomic DNA can be prepared using several ... membranes and proteins (4). Large DNA is quite ***susceptible to mechanical shearing*** and it ...
www.promega.com/guides/re_guide/chaptwo/2_4.htm - 36k - En cache - Pages similaires

Evaluation of a method for high yield purification of largely... associated with cloning such a high molecular weight plasmid ... of the manipulation of a large DNA molecule, which is ***highly susceptible to shearing forces*** ...
www.funpecrp.com.br/gmr/year2003/ vol2-2/gmr0054_full_text.htm - 28k


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Note added at 2003-07-07 04:51:39 (GMT)
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Translation of sentence you gave:

Genomic DNA has a high molecular weight, which makes it highly susceptible to shearing / cleavage / scission.

Cleavage and scission being, of course, synonyms of shearing.

I hope that helps. Does it seem to fit in with the broader context of your translation?
Selected response from:

zhdim
Grading comment
Many thanks for your help - it does indeed fit in with the broader context of the translation.

Best regards,

Allan Wier
4 KudoZ points were awarded for this answer

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Summary of answers provided
5 +2susceptible to shearingzhdim


  

Answers


31 mins   confidence: Answerer confidence 5/5 peer agreement (net): +2
susceptible to shearing


Explanation:
Hi Allan,

A bit of a tough one, but I think I have found some good sites which explain what is going on. The Scher- part is short for Scherung, Scherkraft, which is shearing. I found the following (simple) warning in a site:

Hochmolekular => Scherung!

New Protocols for Isolating High- Molecular-Weight Genomic DNA - ... of the DNA —the point in purification methodology where DNA is most ***susceptible to shearing forces***. Fully hydrated high-molecular-weight DNA is ready to use ...
www.stratagene.com/vol12_2/p66-67.htm -
... High molecular weight genomic DNA can be prepared using several ... membranes and proteins (4). Large DNA is quite ***susceptible to mechanical shearing*** and it ...
www.promega.com/guides/re_guide/chaptwo/2_4.htm - 36k - En cache - Pages similaires

Evaluation of a method for high yield purification of largely... associated with cloning such a high molecular weight plasmid ... of the manipulation of a large DNA molecule, which is ***highly susceptible to shearing forces*** ...
www.funpecrp.com.br/gmr/year2003/ vol2-2/gmr0054_full_text.htm - 28k


--------------------------------------------------
Note added at 2003-07-07 04:51:39 (GMT)
--------------------------------------------------

Translation of sentence you gave:

Genomic DNA has a high molecular weight, which makes it highly susceptible to shearing / cleavage / scission.

Cleavage and scission being, of course, synonyms of shearing.

I hope that helps. Does it seem to fit in with the broader context of your translation?


    Reference: http://www.promega.com/guides/re_guide/chaptwo/2_4.htm
    Reference: http://www.funpecrp.com.br/gmr/year2003/vol2-2/gmr0054_full_...
zhdim
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
Grading comment
Many thanks for your help - it does indeed fit in with the broader context of the translation.

Best regards,

Allan Wier

Peer comments on this answer (and responses from the answerer)
agree  Jonathan MacKerron: or "prone to shear"?
2 hrs

agree  David Moore
3 hrs
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