English translation: norepinephrine reuptake inhibition mechanism
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Explanation: "Noradrenerg" is "noradrenergic", "Wiederaufnahmehemmung" is equivalent to "reuptake/re-uptake inhibition".
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"Male patients were eligible if they (1) were between ages 18 and 55 years, (2) had a diagnosis of MDD in remission, (3) were taking an antidepressant with a selective or nonselective serotonin ***reuptake inhibition mechanism*** for at least 12 weeks, (4) were on a stable dose for at least 6 weeks, and (5) were experiencing AASD for at least 4 weeks."
"The (+) enantiomer has more potency through the mechanisms of opioid receptor agonism and serotonin reuptake inhibition, while the (-) enantiomer has more potency through the norepinephrine ***reuptake inhibition mechanism*** (5). The complementary and synergistic actions of the two enantiomers improve the analgesic efficacy and tolerability profile of the racemate."
Steffen Walter Germany Local time: 17:52 Specializes in field Native speaker of: German PRO pts in category: 170