19:29 Jul 24, 2011 

"In the case of possible prior administration of theophylline or its compounds, reduction of the initial dose may have to be considered."

I would not use "pre-medication".

19:09 Jul 24, 2011 

What it wants to say is that the initial dose should be reduced if theophylline has already been given. I would say something like: When determining the initial dose, any prior administration of theophylline or its compounds should be taken into account and the dose adjusted down accordingly.