Together, these substances are/could be responsible
Explanation: IMO, your interpretation is right, but more context is needed.
en.wikipedia.org/wiki/Cyclooxygenase - CachedCyclooxygenase-2 (Prostaglandin Synthase-2) in complex with a COX-2 ... The resulting inhibition of prostaglandin and thromboxane synthesis has the effect of ... associated with COX-2 inhibitors, with a decreased risk of peptic ulceration. ...
Non-steroidal anti-inflammatory drugs, such as aspirin and ibuprofen, exert their ... The resulting inhibition of prostaglandin and thromboxane synthesis has the effect of ... Some NSAIDs are also acidic which may cause additional damage to the ... associated with COX-2 inhibitors, with a decreased risk of peptic ulceration. ...
hyper.ahajournals.org/content/29/1/274.fullby S Taddei - 1997 - Cited by 147 - Related articles
To evaluate whether cyclooxygenase constrictor substances can impair nitric ... the synthesis of cyclooxygenase-dependent EDCF.13 Thus taken together these ... with the L-arginine pathway, causing NO destruction.10,15 Thus the present ...
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