Tubulusgift
English translation: tubular poison or tubular toxin
| 17:55 Jul 4, 2003 |
| German to English translations [PRO] Medical / cytostatic drugs | |||||||
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|  Selected response from: Jarema Ukraine Local time: 03:21 | ||||||
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| 4 | substance which produces inhibition of microtubule assembly |
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| 3 | tubular poison or tubular toxin |
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Answers
32 mins confidence: 
substance which produces inhibition of microtubule assembly Explanation: May be this help you: Vincristine and vinblastine act primarily by binding to vital intracellular microtubular proteins, particularly tubulin. Tubulin binding produces***inhibition of microtubule assembly***and destruction of the mitotic spindle, causing cells to be arrested in mitosis. Generally, this class of antineoplastic agent is believed to be cell cycle specific. At high concentrations, these drugs also have effects on nucleic acid and protein synthesis. |
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54 mins confidence:
tubular poison or tubular toxin Explanation: Amphotericin B regularly causes acute tubular necrosis, which is so bad it tends to calcify. Cyclosporine, for renal and other transplants, is also a renal glomerular and tubular poison. http://www.pathguy.com/lectures/env-23.htm Resistance to renal injury was also recognized when the kidney was conditioned by dissimilar insults; for example, rats recovering from tubular injury induced by hypertonic glycerol were resistant to tubular damage induced by the tubular toxin, mercuric choride (15); rats treated with tubular toxins such as potassium dichromate (16) or mercuric chloride (17) exhibited reduced sensitivity to the nephrotoxic actions of gentamicin. http://www.jci.org/cgi/content/full/98/9/2139 Tubulus engl.: tubule (latein.) Röhrchen; s.u. Tubuli. Verwandte Themen Corpuscula; Henle* Kanal; Mittelstück; Nephron(um); Nierentubulus; tubulär, tubularis; Tubuli; Überleitungsstück -------------------------------------------------------------------------------- Roche Lexikon Medizin, 4.Auflage; © Urban & Fischer Verlag, München 1984/1987/1993/1999 http://www.gesundheit.de/roche/ro37500/r39729.html Reference: http://www.pathguy.com/lectures/env-23.htm Reference: http://www.jci.org/cgi/content/full/98/9/2139 |
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