Wirkungsentfaltung

English translation: onset of action

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

German term or phrase:	Wirkungsentfaltung
English translation:	onset of action
Entered by:	Trudy Peters

16:39 Jul 8, 2003

German to English translations [PRO]
Medical - Medical: Pharmaceuticals

German term or phrase: Wirkungsentfaltung

Die Wirkungsentfaltung der neurotoxischen Substanzen

There has to be a better word for Entfaltung than development

Trudy Peters KudoZ activity Questions: 883 (1 open) (1 without valid answers) (7 closed without grading) Answers: 3237 United States
Local time: 15:48

onset of action

Explanation:
"The onset of action of antidepressant drugs was investigated on the basis of two independent multicenter, double-blind efficacy studies comparing amitriptyline (N=120), oxaprotiline (N=120), imipramine (N=506) and moclobemide (N=580) with placebo (N=189+191). The samples consisted of in- and out-patients diagnosed, according to DSM-III criteria, as suffering from major depressive disorder."
http://www.bli.unizh.ch/BLI/Projects/psychopharmacology/K274...

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Note added at 2003-07-08 19:49:18 (GMT)
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\"Pharmacokinetics are summarized in a succinct manner: onset of action, peak effect and duration of action.\"

http://www.medicinehouse.com/AboutHandbook.html

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Note added at 2003-07-08 19:51:14 (GMT)
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Alternatively: onset of neurotoxic effects

www.essaim.ca/eng/sante/archives/aout2002a.htm

grants.nih.gov/grants/guide/pa-files/PA-95-005.html

www.sgpharma.com/company/products/vincristine.htm

Selected response from:

Ino66 (X)

Grading comment

That's what I ended up using. Thanks to everyone for some good suggestions!

Trudy
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +1

action

jerryk (X)

onset of action

Ino66 (X)

2 +2

effect

Edith Kelly

3 +1

effect activation

T_Herrmann (X)

impact

Harald Moelzer (medical-translator)

development

Cilian O'Tuama

trends and effects

Norbert Hermann

Answers

56 mins confidence:

peer agreement (net): +2

effect

Explanation:
onset of effect

simple but ... may be

Edith Kelly
Switzerland
Local time: 21:48
Specializes in field
Native speaker of:

German,

English
PRO pts in category: 286

57 mins confidence:

trends and effects

Explanation:
maybe?

Chem-Bank von SilverPlatter umfaßt 5 Chemiedatenbanken: RTECS (Registry of Toxic
Effects of Substances): gibt Auskunft über die toxischen Eigenschaften mit

Third tier level: Working Group on Concentrations, Trends and
Effects of Substances in the Marine Environment (SIME); Working

Norbert Hermann
Local time: 20:48
Native speaker of:

English,

German
PRO pts in category: 8

1 hr confidence:

peer agreement (net): +1

effect activation

Explanation:
medical:

action of a drug

thus, effects of a drug or toxic substance are "activated".

WebMD is a good reference. Just trying :)

T_Herrmann (X)
Local time: 21:48
Native speaker of:

German,

English

1 hr confidence:

peer agreement (net): +1

action

Explanation:
Animal models of Parkinson's disease: an empirical comparison ...
... The partial elucidation of the processes underlie the selective action of neurotoxic substances such as 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6 ...
www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retr... tract
Neurotoxicity: Identifying and Controlling Poisons of the Nervous ... (PDF)
Page 1. Chapter 3 Fundamentals of neurotoxicology ‘ ‘The upsurge of interest in recent years in academia, industry, and government ...
www.wws.princeton.edu/cgi-bin/byteserv.prl/~ota/disk2/1990/... view as html
Neurotoxicity: Identifying and Controlling Poisons of the Nervous ...
... Determining the mechanism of action of neurotoxic substances often requires researchers to investigate possible adverse effects on a variety of receptors and ...
www.mindfully.org/Pesticide/Neurotoxicity-Identifying-Contr... cached

jerryk (X)

1 hr confidence:

impact

Explanation:
...another idea

Harald Moelzer (medical-translator)
Germany
Local time: 21:48
Specializes in field
Native speaker of:

German
PRO pts in category: 317

2 hrs confidence:

development

Explanation:
I reckon 'development' is the best if the above is a heading.

If you can use a verbal phrase, then (depending on the context) maybe sth. like:

the effect of neurotoxic substances (o. neurotoxins)
materializes
evolves from
is generated by/as a result of
emanates from
is attributable/can be attributed to

Probably not much help...

Cilian O'Tuama
Germany
Local time: 21:48
Specializes in field
Native speaker of: English
PRO pts in category: 160

3 hrs confidence:

onset of action

Ino66 (X)
Native speaker of:

Greek
PRO pts in category: 8

Grading comment

That's what I ended up using. Thanks to everyone for some good suggestions!

Trudy

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