GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||
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13:08 Aug 13, 2001 |
German to English translations [Non-PRO] Medical | ||||
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| Selected response from: Ulrike Lieder (X) Local time: 13:39 | |||
Grading comment
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Summary of answers provided | ||||
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na +1 | PDE IV inhibitor or Phosphodiesterase IV Inhibitor |
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PDE IV inhibitor or Phosphodiesterase IV Inhibitor Explanation: See some references: Bayer's Phosphodiesterase IV inhibitor has been undergoing clinical testing since 1999 - in both patients with asthma and with chronic bronchitis. ... www.webhealthplus.com/news/archives/reports/150700asthmacur... Chiroscience Announces PDE IV Progress and R&D updates Phase I study will assess the safety, tolerability and effects on key asthma inflammatory mediators of D4418, an oral PDE IV inhibitor Research updates to be held 30 May and 2 June; AGM to be held 4 June Chiroscience Group plc today announces the initiation of a Phase I study on D4418, an oral phosphodiesterase (PDE) type IV inhibitor being developed to treat asthma. This double blind, placebo controlled study in healthy male volunteers will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of D4418 following administration of ascending single oral doses. In addition, the study will investigate the effects of D4418 on plasma levels of key asthma inflammatory mediators. www.medeva.co.uk/company_information/press_releases/chirosc... pr970513.html Phosphodiesterase IV Inhibitors as Therapy for Eosinophil- ... ... drugs is the cyclic AMP-specific phosphodiesterase (PDE) or PDE IV. This isozyme ... examine the effect of the PDE IV inhibitor, R-rolipram, on three key ... ehpnet1.niehs.nih.gov/docs/1994/Suppl-10/torphy.html ... Inhibitory Effect of a Novel Phosphodiesterase IV Inhibitor, T-440, on Antigen- and Chemical Mediator-Induced Bronchoconstrictions in Guinea Pigs In Vivo. ... wwwsoc.nii.ac.jp/tjps/kyoto/jjp/TOC96-72(1)/96-72-001.html HTH |
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