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Explanation: Polydimethylsiloxane Polydimethylsiloxane polymers are used in surgical procedures such as implants for plastic surgery, as components for catheters, to encase electrode and pacemaker leads, and in prostheses. Reports on the sensitizing potential of silicone are controversial and incomplete, particularly pertaining to its action as an irritant and inducer of inflammation. The objective of this study was to determine the sensitizing potential of polydimethylsiloxane fluid by the dermal route in mice.