fotoapteni
English translation: PHOTOHAPTEN
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| 08:48 Sep 4, 2008 |
| Italian to English translations [PRO] Medical - Medical (general) | |||||||
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|  Selected response from: Donatella Talpo Spain Local time: 05:40 | ||||||
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| 5 +2 | PHOTOHAPTEN |
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| 5 | photoallergens |
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Answers
6 mins confidence: 
peer agreement (net): +2
peer agreement (net): +2PHOTOHAPTEN Explanation: diz. medico |
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| Reference Reference information: http://books.google.com/books?id=z_Rm0rnlMLsC&pg=PA681&lpg=P... Immunotoxicology and Immunopharmacology - Google Books Resultby Jack H. Dean - 1994 - Medical - 761 pages 39 Predictive Models for Assessment of Contact Photoallergy G. ... transport the processed antigenic determinant (photo- hapten) to regional lymph nodes. ... books.google.com/books?isbn=0781702194... |
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1 day 14 hrs |
| Reference Reference information: Photochem Photobiol, 1996 Nov, 64(5), 838 - 44 Photohaptenic properties of fluoroquinolones; Tokura Y et al.; Although quinolone antibacterial agents have both phototoxicity and photoallergenicity, the latter's potency has been poorly investigated compared with the former's . Some of the photoallergic chemicals serve as photohaptens, which lead to T-cell-mediated immune reactions after photobinding to protein by UVA radiation . We examined the photohaptenic potential of fluoroquinolones, including lomefloxacin (LFLX), ciplofloxacin, norfloxacin, ofloxacin, levofloxacin, fleroxacin, enoxacin and sparfloxacin (SPFX) . The absorption spectra of the quinolones were altered by UVA irradiation, with an exception of SPFX that seems to be photostable toward UVA . Bovine serum albumin and murine epidermal cells were coupled with these fluoroquinolones other than SPFX by exposure to UVA . Subcutaneous inoculation of fluoroquinolone-photomodified epidermal cells induced and elicited a delayed-type hypersensitivity reaction in mice . However, epidermal cells incubated with LFLX without UVA exposure also induced and elicited a significant hypersensitivity reaction to a lesser degree than LFLX-photomodified epidermal cells . Furthermore, there was cross-reactivity between LFLX-photomodified epidermal cells and simply LFLX-incubated cells . This suggests that cells can be weakly modified with LFLX even in the dark and that UVA irradiation promotes this modification . Our study demonstrated that fluoroquinolones have photohaptenic properties to which their photoallergenicity is probably ascribed. A photohaptenic moiety is one of the salient properties of photoallergic chemicals. Clinically, it is likely that photohaptens are the main causative substances in photoallergic contact dermatitis and drug photoallergy. Photohaptens bind covalently to protein under exposure to ultraviolet A light (UVA). Because of this photocoupling ability, cells are easily photoderivatized with a photohapten by UVA irradiation, becoming immunogenic photohapten-modified cells. Langerhans cells photomodified with a photohapten can stimulate immune T cells when photomodification is performed with a non-phototoxic dose of UVA. # k=1163071 - 595k - Cached - Similar pages # Expert Opinion - Expert Opinion on Drug Safety - 6(4):431 - Full Text GERBERICK GF, RYAN CA, VON BARGEN EC, STUARD SB, RIDDER GM: Examination of tetrachlorosalicylanilide (TCSA) photoallergy using in vitro photohapten-modified ... www.informapharmascience.com/doi/abs/10.1517/14740338.6.4.4... - Similar pages by KR Stein - 2007 - Cited by 1 - Related articles - All 3 versions # Immunotoxicology and Immunopharmacology In the case of photoallergic contact dermatitis, a “photohapten” becomes activated via ultraviolet A irradiation and binds to proteins, including those on ... www.docstoc.com/docs/1080821/Immunotoxicology-and-Immunopha... - 977k - Cached - Similar pages # [PDF] P O S T E R S File Format: PDF/Adobe Acrobat cases, as well as due to the formation of photohapten. We. have investigated photophysical properties of three such. quinolones and determined the triplet ... www.kumc.edu/POL/ASP_Home/ASP-2006-abstracts.pdf - Similar pages |
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