aneuploidia deleteria

English translation: deleterious aneuploidy

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Italian term or phrase:aneuploidia deleteria
English translation:deleterious aneuploidy
Entered by: Frances Leggett

20:09 Apr 24, 2014
Italian to English translations [PRO]
Medical - Medical: Pharmaceuticals / clinical trials
Italian term or phrase: aneuploidia deleteria
Uno studio di fase 2 ha evidenziato risultati particolarmente incoraggianti in pazienti con linfoma periferico a cellule T (peripheral T-cell lymphoma, PTCL) recidivante o refrattario, costituendo la base per lo studio globale di fase 3 attualmente in corso su XXXX come singolo agente nel PTCL.
L’inibizione di Aurora A ha determinato l’interruzione dell’assemblaggio del fuso mitotico, causando ritardo mitotico, errori di segregazione dei cromosomi, aneuploidia deleteria e, infine, la morte delle cellule.
$$$$ interrompe il funzionamento dei microtubuli e impedisce il corretto assemblaggio dei fusi mitotici, determinando un arresto mitotico prolungato e, alla fine, la morte delle cellule.

XXXX and $$$$ are drug names.
I'm unsure of how to translate "deleteria" here. There are only about 351 Google hits for "deleterious aneuploidy".
I would appreciate a medical expert's assistance on what the correct translation for this term would be in English.
Thanks in advance!
Frances Leggett
United Kingdom
Local time: 18:02
harmful aneuploidy
Explanation:
"deleteria" here does not refer to a "deletion" - rather the fact that aneuploidy is harmful, dangerous, etc.

"Defects in chromosome segregation and cytokinesis can result in harmful aneuploidy that can lead to birth defects, tumorigenesis, and lethality"
Selected response from:

Erin Lyons
United States
Local time: 13:02
Grading comment
I'm actually going to use "deleterious" as the main adjective here because I actually found more hits with "deleterious aneuploidy" than with any other synonymous adjective.
3 KudoZ points were awarded for this answer



Summary of answers provided
4harmful aneuploidy
Erin Lyons
2aneuploidy by deletion
Anne Schulz


Discussion entries: 8





  

Answers


15 hrs   confidence: Answerer confidence 2/5Answerer confidence 2/5
aneuploidy by deletion


Explanation:
Deletion of a larger chromosomal portion can result in partial monosomy (=aneuploidy).



Anne Schulz
Germany
Local time: 19:02
Specializes in field
Native speaker of: German
PRO pts in category: 4
Login to enter a peer comment (or grade)

15 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
harmful aneuploidy


Explanation:
"deleteria" here does not refer to a "deletion" - rather the fact that aneuploidy is harmful, dangerous, etc.

"Defects in chromosome segregation and cytokinesis can result in harmful aneuploidy that can lead to birth defects, tumorigenesis, and lethality"

Example sentence(s):
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653428/
Erin Lyons
United States
Local time: 13:02
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 3
Grading comment
I'm actually going to use "deleterious" as the main adjective here because I actually found more hits with "deleterious aneuploidy" than with any other synonymous adjective.
Login to enter a peer comment (or grade)



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