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Science - Biology (-tech,-chem,micro-) / descripcion de puesto | | Spanish term or phrase: gráneles (con tilde en la "A") | | Las vacunas de bacterias completas o de componentes bacterianos son preparadas en medios artificiales de crecimiento bien caracterizados a través del proceso de fermentación. El producto final de fermentación llamado cosecha, es procesado para obtener gráneles concentrados y purificados, los cuales se pueden almacenar por largos períodos hasta el momento de formular la vacuna |
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Catalina Connon
Argentina
Local time: 21:57
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11 hrs confidence: peer agreement (net): +1 | gráneles (con tilde en la [concentrated and purified] bulk product/material
Explanation:
See:
Collins Sp-En Dictionary:
Granel: nm (montón) heap; a granel in abundance…..vino a granel: wine in bulk or in the barrel
http://66.102.9.104/search?q=cache:vnEtNvemCtMJ:coli.usal.es...
Production of the components of bacterial vaccines
The bacteria and bacterial components needed for the manufacture of bacterial vaccines are readily prepared in laboratory media by wellrecognised fermentation methods. The end-product of the fermentation, the harvest, is processed to provide a concentrated and purified vaccine component that may be conveniently stored for long periods or even traded as an article of commerce.
- Medios liquidos/solidos Fermentadores
Fermentation
The satisfactory growth of a bacterial seed into the bulk material necessary for vaccine production is critically dependent on the provision of optimal cultural conditions. Liquid media, when capable of providing such conditions, are always preferred to solid media for production purposes as they can be used in large fermenter vessels and so obviate the labour-intensive manipulation of the numerous smaller vessels needed for solid media. Media are prepared whenever possible from chemically defined materials, or at least from approximately defined materials such as digested casein, in order to reduce batch variation to a minimum.
- Siembra en medio de preproducción
The production of a bacterial vaccine batch begins with the breaking-out of the seed and its growth through one or more passages in preproduction media. The organisms grown in the preproduction media are used to inoculate the production medium, which may be either in a large number of relatively small containers or in a single large fermenter. Fermentation is always carefully regulated and monitored. When small containers are used they may be stationary or shaken; when a fermenter is used the contents are continuously mixed and the pH and oxidation-reduction potential of the medium are often monitored and adjusted throughout the growth period. In the case of rapidly growing organisms this period may be as short as a few hours but in the case of slowly growing organisms as long as two weeks. At the end of the growth period, cultures in small containers are pooled to form a bulk harvest; fermenter batches are often sufficiently large to be processed without pooling.
Manufacturing of Conjugate Vaccines
Purified bulk saccharides, when trimmed, have to be sorted into size classes ... For some vaccines, the product is multivalent — that is, it is comprised of ...
www.pall.com/biopharm_36519.asp - 17k - Cached - Similar pages
Process Development and Analysis of Liver-Stage Antigen 1, a ...
4). The final yield of LSA-NRC was 230 mg liter of fermentation culture−1. Product analysis. The HCP content of the purified bulk product, as determined by ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1087442 - Similar pages
Efficacy of Two Alternate Vaccines Based on Plasmodium falciparum ...
(ii) Host cells and fermentation. Plasmids were used to transform an S. cerevisiae ... Each condition gave rise to a slightly different purified product, ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98053 - Similar pages
[PDF] CONTROL AUTHORITY BATCH RELEASE OF VACCINES AND BLOOD PRODUCTS
File Format: PDF/Adobe Acrobat
Release of Hepatitis B (rDNA) Vaccine. · Harvests : refer to section 3.2.2.1. · Purified bulk : refer to section 3.2.2.2. 3.2.2.3 Adsorbed bulk concentrates ...
www.tga.gov.au/docs/pdf/euguide/ocabr09.pdf - Similar pages
[PDF] Process Development and Analysis of Liver-Stage Antigen 1, a ...
File Format: PDF/Adobe Acrobat
mg liter of fermentation culture. 1 . Product analysis. The HCP content of the purified bulk. product, as determined by quantitative ELISA, was 7 ng of ...
iai.asm.org/cgi/reprint/73/4/2109.pdf - Similar pages
|  liz askew
United Kingdom
Local time: 01:57
Native speaker of:  English
PRO pts in category: 86
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