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C-ANCA

English translation: C-ANCA


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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:C-ANCA
English translation:C-ANCA
Entered by: xxxOso
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19:55 Aug 3, 2005
Spanish to English translations [PRO]
Medical - Medical: Health Care / medical report
Spanish term or phrase: C-ANCA
Paciente en tratamiento de Hemodia'lisis por una glomerulonefritis necrotizante rapidamente progresiva que debuto' con un cuadro de hemoptisis con C-ANCA...
Zareh Darakjian Ph.D.
Local time: 01:22
C-ANCA
Explanation:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...

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Note added at 2005-08-03 20:02:37 (GMT)
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\"...Renal transplantation in a ***C-ANCA***(+) patient with Behcet disease and rapidly progressive glomerulonephritis.
Moises J, Torregrosa JV, Ybarra J, Oppenheimer F.
Renal Transplant Unit, Hospital Clinic i Provincial, Barcelona, Spain.
Behcet\'s disease (BD) is a chronic, relapsing, inflammatory disorder, and the underlying histophatological lesion is vasculitis of unknown cause. Some case reports of BD with positive C-ANCA titers have been reported, but only 2 case reports have documented the association of ANCA-associated glomerulonephritis (GN) and BD, and no renal transplantation cases have been described. We report such a case. A 27-year-old male was referred for consultation due to acute renal failure. Seven years before, BD was diagnosed. At the time of consultation he suffered from uveitis and generalized arthralgias. The serum creatinine was 14 mg/dl and urinalysis showed 4+ protein and microscopic hematuria. Results of serological tests were normal. The ANCA PR 3 titer was 1:100 of cytoplasmic pattern. A renal biopsy showed a rapidly progressive type III glomerulonephritis. In spite of immunosuppressive therapy with cyclophosphamide and high steroid doses, renal function did not recover and hemodialysis therapy was initiated. One year later, the patient underwent a renal transplantation. Follow-up was absolutely normal, and 5 years after transplantation, renal function persisted to be normal, without urinary abnormalities and signs of reactivation of original disease, except for occasional arthralgias. ***C-ANCA*** titer was decreased and remained stable (<1:30). He is now receiving maintenance immunosupression with cyclosporin and prednisone. This report shows the long-term successful renal transplantation in a patient with ANCA-associated glomerulonephritis and BD. The success of renal transplant in BD with renal involvement is encouraging and should be pursued. \"

Good luck from Oso ¶:^)

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Note added at 2005-08-03 20:06:03 (GMT)
--------------------------------------------------

También hay mucha información acerca de ANCA y C-ANCA en este enlace:

http://www.thedoctorsdoctor.com/diseases/anca.htm

\"ANCA stands for anti-neutrophilic cytoplasmic antibodies.\"

\"C-ANCA Coarsely granular cytoplasmic pattern with central and interlobular accentuation\"
Selected response from:

xxxOso
Grading comment
Thank you very much, Oso!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +4C-ANCAxxxOso


Discussion entries: 1





  

Answers


5 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +4
C-ANCA


Explanation:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...

--------------------------------------------------
Note added at 2005-08-03 20:02:37 (GMT)
--------------------------------------------------

\"...Renal transplantation in a ***C-ANCA***(+) patient with Behcet disease and rapidly progressive glomerulonephritis.
Moises J, Torregrosa JV, Ybarra J, Oppenheimer F.
Renal Transplant Unit, Hospital Clinic i Provincial, Barcelona, Spain.
Behcet\'s disease (BD) is a chronic, relapsing, inflammatory disorder, and the underlying histophatological lesion is vasculitis of unknown cause. Some case reports of BD with positive C-ANCA titers have been reported, but only 2 case reports have documented the association of ANCA-associated glomerulonephritis (GN) and BD, and no renal transplantation cases have been described. We report such a case. A 27-year-old male was referred for consultation due to acute renal failure. Seven years before, BD was diagnosed. At the time of consultation he suffered from uveitis and generalized arthralgias. The serum creatinine was 14 mg/dl and urinalysis showed 4+ protein and microscopic hematuria. Results of serological tests were normal. The ANCA PR 3 titer was 1:100 of cytoplasmic pattern. A renal biopsy showed a rapidly progressive type III glomerulonephritis. In spite of immunosuppressive therapy with cyclophosphamide and high steroid doses, renal function did not recover and hemodialysis therapy was initiated. One year later, the patient underwent a renal transplantation. Follow-up was absolutely normal, and 5 years after transplantation, renal function persisted to be normal, without urinary abnormalities and signs of reactivation of original disease, except for occasional arthralgias. ***C-ANCA*** titer was decreased and remained stable (<1:30). He is now receiving maintenance immunosupression with cyclosporin and prednisone. This report shows the long-term successful renal transplantation in a patient with ANCA-associated glomerulonephritis and BD. The success of renal transplant in BD with renal involvement is encouraging and should be pursued. \"

Good luck from Oso ¶:^)

--------------------------------------------------
Note added at 2005-08-03 20:06:03 (GMT)
--------------------------------------------------

También hay mucha información acerca de ANCA y C-ANCA en este enlace:

http://www.thedoctorsdoctor.com/diseases/anca.htm

\"ANCA stands for anti-neutrophilic cytoplasmic antibodies.\"

\"C-ANCA Coarsely granular cytoplasmic pattern with central and interlobular accentuation\"


    Reference: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
xxxOso
Native speaker of: Native in SpanishSpanish
PRO pts in category: 36
Grading comment
Thank you very much, Oso!

Peer comments on this answer (and responses from the answerer)
agree  Hugo Silva: Exacto, Oso... Saludos...:-))
1 hr
  -> Muchas gracias, Hugo ¡Saludos cordiales! ¶:^)

agree  Muriel Vasconcellos
3 hrs
  -> Muchas gracias, Muriel ¶:^)

agree  David Brown
10 hrs
  -> Muchas gracias, David ¶:^)

agree  MargaEsther
20 hrs
  -> Saludos y mil gracias, Marga ¶:^)
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