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la concentración terapéutica libre máxima

English translation: maximum free therapeutic (drug) concentration

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:la concentración terapéutica libre máxima
English translation:maximum free therapeutic (drug) concentration
Entered by: Adam Burman
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20:24 Oct 28, 2006
Spanish to English translations [PRO]
Medical - Medical: Pharmaceuticals / Investigator's/researcher's brochure
Spanish term or phrase: la concentración terapéutica libre máxima
Se acepta en general que compuestos con un valor de IC50  10 M en el análisis de hERG y una relación de exposición de  30 (sobre la base de la IC50 en el análisis hERG y la concentración terapéutica libre máxima) no van a causar prolongación del QTc en el ECG superficial. , Sobre la base del valor IC42 de 195 M para desvenlafaxina y un valor de IC50  10 M para su metabolito NODV y una relación de exposición de 90 a la concentración terapéutica libre máxima para desvenlafaxina, la administración de DVS SR tabletas no afectaría la electrofisiología cardiaca a dosis clínicamente relevantes.

TIA
Adam Burman
United Kingdom
Local time: 11:02
maximum free therapeutic concentration
Explanation:
Measurement of free concentration is necessary to determine the effective or bioavailable quantity of a chemical
Selected response from:

isabellev50
Spain
Local time: 12:02
Grading comment
Thanks Isabelle!
4 KudoZ points were awarded for this answer

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Summary of answers provided
4 +3maximum free therapeutic concentration
isabellev50


  

Answers


4 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
maximum free therapeutic concentration


Explanation:
Measurement of free concentration is necessary to determine the effective or bioavailable quantity of a chemical


isabellev50
Spain
Local time: 12:02
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
Grading comment
Thanks Isabelle!

Peer comments on this answer (and responses from the answerer)
agree  Cinnamon Nolan
41 mins

agree  Dr. Jason Faulkner
4 hrs

agree  Sonia Iujvidin
4 hrs

neutral  David Brown: "terapeutica" in this context means "drug"
10 hrs
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