Mast cells (which are Leukocytes) contain metachromatic granules which store a variety of inflammatory mediators. These include:
Histamine and serotonin.
Proteolytic enzymes that can destroy tissue or cleave complement components.
Heparin or chondroitin sulfate, which are anticoagulants.
Chemotactic factors, such as eosinophil chemotactic factor of anaphylaxis (an important regulator of eosinophil function) and neutrophil chemotactic factor.
Normally, mast cells are not found in circulation.
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