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Spanish to English translations [PRO]
Medical - Medical (general) / Research report for new drug | | Spanish term or phrase: fue mayor que la proporcional a la dosificación entre | En cambio, en el estudio de toxicidad oral por sonda orogástrica de 26 semanas de duración realizado en ratas, el aumento en la exposición fue mayor que la proporcional a la dosificación entre 100 y 300 mg/Kg/día, y a dosificaciones de entre 30 y 300 mg/Kg/día, las ratas hembra tuvieron una exposición más alta que los machos.
Draft: By contrast, in the 26 week duration oral toxicity study via orogastric tube in rats, the increase in exposure was greater than... 100 and 300 mg/Kg/day, and at doses of between 30 and 300 mg/Kg/day, the female rats were subject to higher exposure than the males.
Bit unsure on this part. Suggestions?
Many thanks |
| | | was greater than the dose-proportional exposure for a dose range of | Explanation:
Thanks for draft, always very helpful:-)
Draft: By contrast, in the 26 week duration oral toxicity study via orogastric tube in rats, the increase in exposure was greater than... 100 and 300 mg/Kg/day, and at doses of between 30 and 300 mg/Kg/day, the female rats were subject to higher exposure than the males.
Second part (new sentence):
y a dosificaciones de entre 30 y 300 mg/Kg/día, las ratas hembra tuvieron una exposición más alta que los machos.
At doses of between 30 and 300 mg/Kg/day, furthermore, the exposure of the female rats was higher than that of the male rats.
Alternative 1 for first part (literal):
En cambio, en el estudio de toxicidad oral por sonda orogástrica de 26 semanas de duración realizado en ratas, el aumento en la exposición fue mayor que la proporcional a la dosificación entre 100 y 300 mg/Kg/día,
In contrast, in the 26-week long orogastric-tube toxicity study in rats, the increase in exposure was greater than the proportional exposure to doses of between 100 and 300 mg/Kg/day.
Alternative 2 (educated guess):
En cambio, en el estudio de toxicidad oral por sonda orogástrica de 26 semanas de duración realizado en ratas, el aumento en la exposición fue mayor que la proporcional a la dosificación entre 100 y 300 mg/Kg/día,
In contrast, in the 26-week long orogastric-tube toxicity study in rats, the increase in exposure was greater than the dose-proportional exposure for a dose range of 100 to 300 mg/Kg/day.
References:
[PDF] C:\Data\Lei's folder\Review reports\NDA-550\NDA-21042\SE5-S026\re ...
File Format: PDF/Adobe Acrobat - View as HTML
dose-proportional exposure in the effective dose ranges in JRA and RA patients. In fact,. clearance data from adult RA patients was 32% lower than that in ...
www.fda.gov/cder/foi/esum/2004/21042se5-026,21052se5-019_Vi... - Similar pages
Clinical Trial Results by Drug Names
The Fuzeon 75mg bid dose had a slightly higher than dose-proportional exposure. Trough enfuvirtide concentrations for the Fuzeon 75mg and 100mg bid dose ...
www.roche-trials.com/patient/trialresults/stur18.html - 46k - Cached - Similar pages
Tolerability and steady-state pharmacokinetics of everolimus in ...
These results indicate that up to 5 mg/day everolimus results in a dose-proportional exposure, and is adequately well tolerated in renal transplant ...
cat.inist.fr/?aModele=afficheN&cpsidt=16189198 - Similar pages
Antifungal efficacy of caspofungin(MK-0991) in experimental ...
The CAS 1, CAS 3, and CAS 6 dose regimens demonstrated dose-proportional exposure and maintained drug levels in plasma above the MIC for the entire 24-h ...
cat.inist.fr/?aModele=afficheN&cpsidt=13442170 - Similar pages
[PDF] A PHASE I DOSE-ESCALATION AND PHARMACOKINETIC (PK) STUDY OF A ...
File Format: PDF/Adobe Acrobat - View as HTML
Preliminary PK analysis indicates that XL647 shows approximately dose-proportional exposure,. with a mean time to maximal concentration (t ...
library.corporate-ir.net/library/12/120/120923/items/174686/XL647.pdf - Similar pages
[PDF] A PHASE I DOSE-ESCALATION AND PHARMACOKINETIC (PK) STUDY OF A ...
File Format: PDF/Adobe Acrobat - View as HTML
XL647 shows approximately dose-proportional exposure, a mean time to maximal concentration (t. max. ) of. 6–9 hours, and an elimination half-life of ...
www.exelixis.com/downloads/XL647-ASCO-Jun2006.pdf - Similar pages
In the dose range of 0. 5-2. 0 mg/kg, acetylsalicylic acid does ...
In the dose range of 0. 5-2. 0 mg/kg/day, ASA has a favorable effect on the ratio of prostacyclin to thromboxane A 2 in hypertensive pregnancies.
cat.inist.fr/?aModele=afficheN&cpsidt=1666091 - Similar pages
The nonclinical safety evaluation of the anticancer drug ATRAGEN ...
Moderate to marked retinoid-associated hypervitaminosis A was observed in the 28-day rats studies in the dose range of 10 to 25 mg/kg/day. ...
cat.inist.fr/?aModele=afficheN&cpsidt=1336704 - Similar pages
[ More results from cat.inist.fr ]
787. Azocyclotin (Pesticide residues in food: 1989 evaluations ...
The weight gain of the dams was reduced at 100 mg/kg/day but the response ... or the fetuses over the dose range of 30 to 300 mg/kg by dermal application. ...
www.inchem.org/documents/jmpr/jmpmono/v89pr03.htm - 12k - Cached - Similar pages
In the dose range of 0.5-2.0 mg/kg, acetylsalicylic acid does not ...
CONCLUSION: In the dose range of 0.5-2.0 mg/kg/day, ASA has a favorable effect on the ratio of prostacyclin to thromboxane A2 in hypertensive pregnancies. ...
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubM... - Similar pages |
| Selected response from:
xxxLia Fail
Spain
Local time: 18:20
| Grading comment Thanks for your help with this Lia. Also very useful refs. Best regards!
4 KudoZ points were awarded for this answer |
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57 mins confidence:  
21 hrs confidence: was greater than the dose-proportional exposure for a dose range of
Explanation:
Thanks for draft, always very helpful:-)
Draft: By contrast, in the 26 week duration oral toxicity study via orogastric tube in rats, the increase in exposure was greater than... 100 and 300 mg/Kg/day, and at doses of between 30 and 300 mg/Kg/day, the female rats were subject to higher exposure than the males.
Second part (new sentence):
y a dosificaciones de entre 30 y 300 mg/Kg/día, las ratas hembra tuvieron una exposición más alta que los machos.
At doses of between 30 and 300 mg/Kg/day, furthermore, the exposure of the female rats was higher than that of the male rats.
Alternative 1 for first part (literal):
En cambio, en el estudio de toxicidad oral por sonda orogástrica de 26 semanas de duración realizado en ratas, el aumento en la exposición fue mayor que la proporcional a la dosificación entre 100 y 300 mg/Kg/día,
In contrast, in the 26-week long orogastric-tube toxicity study in rats, the increase in exposure was greater than the proportional exposure to doses of between 100 and 300 mg/Kg/day.
Alternative 2 (educated guess):
En cambio, en el estudio de toxicidad oral por sonda orogástrica de 26 semanas de duración realizado en ratas, el aumento en la exposición fue mayor que la proporcional a la dosificación entre 100 y 300 mg/Kg/día,
In contrast, in the 26-week long orogastric-tube toxicity study in rats, the increase in exposure was greater than the dose-proportional exposure for a dose range of 100 to 300 mg/Kg/day.
References:
[PDF] C:\Data\Lei's folder\Review reports\NDA-550\NDA-21042\SE5-S026\re ...
File Format: PDF/Adobe Acrobat - View as HTML
dose-proportional exposure in the effective dose ranges in JRA and RA patients. In fact,. clearance data from adult RA patients was 32% lower than that in ...
www.fda.gov/cder/foi/esum/2004/21042se5-026,21052se5-019_Vi... - Similar pages
Clinical Trial Results by Drug Names
The Fuzeon 75mg bid dose had a slightly higher than dose-proportional exposure. Trough enfuvirtide concentrations for the Fuzeon 75mg and 100mg bid dose ...
www.roche-trials.com/patient/trialresults/stur18.html - 46k - Cached - Similar pages
Tolerability and steady-state pharmacokinetics of everolimus in ...
These results indicate that up to 5 mg/day everolimus results in a dose-proportional exposure, and is adequately well tolerated in renal transplant ...
cat.inist.fr/?aModele=afficheN&cpsidt=16189198 - Similar pages
Antifungal efficacy of caspofungin(MK-0991) in experimental ...
The CAS 1, CAS 3, and CAS 6 dose regimens demonstrated dose-proportional exposure and maintained drug levels in plasma above the MIC for the entire 24-h ...
cat.inist.fr/?aModele=afficheN&cpsidt=13442170 - Similar pages
[PDF] A PHASE I DOSE-ESCALATION AND PHARMACOKINETIC (PK) STUDY OF A ...
File Format: PDF/Adobe Acrobat - View as HTML
Preliminary PK analysis indicates that XL647 shows approximately dose-proportional exposure,. with a mean time to maximal concentration (t ...
library.corporate-ir.net/library/12/120/120923/items/174686/XL647.pdf - Similar pages
[PDF] A PHASE I DOSE-ESCALATION AND PHARMACOKINETIC (PK) STUDY OF A ...
File Format: PDF/Adobe Acrobat - View as HTML
XL647 shows approximately dose-proportional exposure, a mean time to maximal concentration (t. max. ) of. 6–9 hours, and an elimination half-life of ...
www.exelixis.com/downloads/XL647-ASCO-Jun2006.pdf - Similar pages
In the dose range of 0. 5-2. 0 mg/kg, acetylsalicylic acid does ...
In the dose range of 0. 5-2. 0 mg/kg/day, ASA has a favorable effect on the ratio of prostacyclin to thromboxane A 2 in hypertensive pregnancies.
cat.inist.fr/?aModele=afficheN&cpsidt=1666091 - Similar pages
The nonclinical safety evaluation of the anticancer drug ATRAGEN ...
Moderate to marked retinoid-associated hypervitaminosis A was observed in the 28-day rats studies in the dose range of 10 to 25 mg/kg/day. ...
cat.inist.fr/?aModele=afficheN&cpsidt=1336704 - Similar pages
[ More results from cat.inist.fr ]
787. Azocyclotin (Pesticide residues in food: 1989 evaluations ...
The weight gain of the dams was reduced at 100 mg/kg/day but the response ... or the fetuses over the dose range of 30 to 300 mg/kg by dermal application. ...
www.inchem.org/documents/jmpr/jmpmono/v89pr03.htm - 12k - Cached - Similar pages
In the dose range of 0.5-2.0 mg/kg, acetylsalicylic acid does not ...
CONCLUSION: In the dose range of 0.5-2.0 mg/kg/day, ASA has a favorable effect on the ratio of prostacyclin to thromboxane A2 in hypertensive pregnancies. ...
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubM... - Similar pages
| xxxLia Fail
Spain
Local time: 18:20
Specializes in field
Native speaker of:  English
PRO pts in category: 100
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| | Grading comment | Thanks for your help with this Lia. Also very useful refs. Best regards! |
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