Working languages: English to French
|  Marie-Pierre GERARD
5 years studying medicine
NA Local time: 09:06 CET (GMT+1)
Native in: French  | | |
Freelancer,  Verified site user | | Translation, Editing/proofreading, Project management | | Specializes in: | | Medical: Cardiology | Medical: Pharmaceuticals | | Medical: Instruments | Medical: Health Care | | Medical (general) |
| Also works in: | | Biology (-tech,-chem,micro-) | Cooking / Culinary | | Cosmetics, Beauty | Medical: Dentistry | | Marketing / Market Research | Mathematics & Statistics | | Nutrition | Tourism & Travel | | Genetics |
More Less | | PRO-level points: 105, Questions answered: 60, Questions asked: 2 | Sample translations submitted: 1 | English to French: Medical | Source text - English
The vascular endothelium of tumour tissue, which differs in several ways from that of normal tissues, is a potential target for selective anticancer therapy. By contrast with antiangiogenic agents, antivascular agents target the endothelial cells of existing tumour blood vessels, causing distortion or damage and consequently decreasing tumour blood flow. DMXAA (5,6-dimethylxanthenone-4-acetic acid), a low-molecular-weight drug, has a striking antivascular and in some cases curative effect in experimental tumours. Its action on vascular endothelial cells seems to involve a cascade of events leading to induction of tumour haemorrhagic necrosis. These events include both direct and indirect effects, the latter involving the release of further vasoactive agents, such as serotonin, tumour necrosis factor, other cytokines, and nitric oxide from host cells. Phase I clinical trials of DMXAA have been completed and the next challenge to face is how the antivascular effect of this drug should be exploited for the treatment of human cancer. | Translation - French
L'endothélium vasculaire du tissu tumoral, très différent en de nombreux points de celui des tissus normaux, est une cible potentielle pour une thérapie anti-cancéreuse sélective. Contrairement aux agents anti-angiogéniques, les agents anti-vasculaires ciblent les cellules endothéliales des vaisseaux sanguins tumoraux déjà existants, causant des déformations et des dommages et diminuant en conséquence le débit sanguin de la tumeur. Le DMXAA (acide 5,6-dimethylxanthenone-4-acétique), une substance à faible poids moléculaire, a un effet anti-vasculaire impressionnant sur les tumeurs expérimentales et parfois même un effet curatif. Son action sur les cellules endothéliales des vaisseaux sanguins semble induire, en cascade, une nécrose hémorragique de la tumeur. Cette action repose à la fois sur des effets directs et indirects : parmi ces derniers la libération d'agents vasoactifs supplémentaires, comme la sérotonine, le facteur de nécrose tumorale, d'autres cytokines et de l'oxyde nitrique venant des cellules hôtes. La Phase I des essais cliniques du DMXAA est terminée et le prochain défi sera de voir comment utiliser l'effet anti-vasculaire de cette substance dans le traitement du cancer chez l'homme. |
More Less | | mpgtraduction | | Years of translation experience: 4. Registered at ProZ.com: Feb 2003. | | N/A | English to French (Université de Paris-Sorbonne Nouvelle (Maîtrise))
| | SFT | | Dreamweaver, Office 2003, Powerpoint, STAR Transit, Wordfast |  CV/Resume (DOC) | | Marie-Pierre GERARD endorses ProZ.com's Professional Guidelines (v1.0). | | About me Translation in biology, medicine and pharmacology fields.
General translation of jobs related to advertising ( cosmetics, educational), press release, NGO reports, user manual (arts and crafts).
MA in English linguistics and translation (translation of a book: mention TB |
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Keywords: médical, médecine, pharmacie, pharmaceutique, laboratoire, notice, mode d\'emploi, scientifique, informatique, site web, article de presse, loisirs
crétifs, travaux manuels, livres pour enfants
medicine, pharmacology, biology, advertising, cosmetics, software, press release, book for children, arts and crafts, user manual, medical device, medical incident reports.
Profile last updated
Feb 24, 2009 |
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