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Working languages: English to Chinese
Chinese to English
| calpain
A medical translator
Beijing, Beijing, China Local time: 15:03 CST (GMT+8)
Native in: Chinese | | Willingness to Work Again  |  No feedback collected |
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Freelancer,  Verified site user | | Translation, Editing/proofreading | | Specializes in: | | Agriculture | Biology (-tech,-chem,micro-) | | Chemistry; Chem Sci/Eng | Medical: Pharmaceuticals | | Medical: Health Care | Medical (general) | | Photography/Imaging (& Graphic Arts) | Patents |
| | PRO-level points: 95, Questions answered: 42, Questions asked: 13 | 0 projects entered
| Sample translations submitted: 3 Chinese to English: 生物学论文
Detailed field: Biology (-tech,-chem,micro-) | Source text - Chinese
本研究结果，在5-Aza-CdR 与NaB 联合应用下，RASSF1A 基因表达较单独应用5-Aza-CdR 上调，表明了甲基化酶抑制剂5-Aza-CdR 及去乙酰化酶抑制剂NaB 在转录调控作用上的协同作用。这与Egger 等 的研究结果一致。研究发现，DNA 甲基化和组蛋白乙酰化对基因表达的调控作用有密切联系。DNA 甲基化可诱导局部组蛋白去乙酰化，使染色质乙酰化水平降低，甲基化CpG 结合蛋白MeCP2 以甲基化依赖的方式结合到染色质上，通过转录抑制结构域与桥蛋白Sin3A 和HDAC 的共同抑制复合体紧密联系。 | Translation - English
Our study shows that combined administration of 5-Aza-CdR and NaB upregulates the gene expression level of RASSF1A as compared with 5-Aza-CdR alone, demonstrating the synergistic action of the methylase inhibitor 5-Aza-CdR and the histone deacetylase inhibitor (HDAC) NaB on transcriptional regulation. This finding is consistent with the study by Egger et al. Previous studies have established that DNA methylation and histone acetylation correlate closely with gene regulation. DNA methylation can induce local histone deacetylation and therefore reduce the acetylation level of chromatins. Methyl-CpG-binding protein MeCP2 binds to chromatins via a methytation-dependent manner and associates tightly with the corepressor complex consisting of HDAC and adaptor protein Sin3A through its transcription repression domain. | Chinese to English: 癌症
Detailed field: Medical (general) | Source text - Chinese
HBx在原发性肝癌发病中的作用
研究表明，HBx不仅出现于细胞质，也见于细胞核内。其作用方式并不是直接与DNA结合，而是通过蛋白质-蛋白质作用，反式激活宿主细胞和病毒基因的启动子，对病毒基因启动子的激活有助于感染的持续和播散。HBx对宿主细胞基因的影响则要广泛而深刻得多。
1.1 激活细胞癌基因
HBx可激活众多的细胞癌基因。HBx 对这些癌基因的激活必将对肝细胞的生长、转化产生重要影响。同时，个别癌基因被激活后，也将对其下游与细胞生长有密切关系的靶基因产生激活作用，从而使其生物效应放大。
| Translation - English
Roles of HBx in the development of primary hepatocellular carcinoma
Studies have shown that HBx is present both in the cytoplasm and the nucleus. HBx protein transactivates the promoters of host cellular genes and viral genes via protein-protein interaction instead of its direct association with DNA. The activation of viral promoters by HBx contributes to the persistence and spread of viral infection. The effects of HBx on the host genes are far more extensive and profound.
1.1 Activation of cellular oncogenes
HBx can activate a variety of cellular oncogenes and thus exerts vital effects on the growth and transformation of hepatocytes. Moreover, some oncogenes, upon activation, will also activate their downstream target genes involved intimately in cell growth, thereby boosting HBx's effects on the host.
| English to Chinese: Novel Anti-Cancer Drug
General field: Medical | Source text - English
Marillion Pharmaceuticals, Inc., a privately-held development-stage pharmaceutical company focused on novel therapeutics for the treatment of cancer, inflammatory and autoimmune diseases, announced today that its investigational new drug application (IND) has been cleared by the FDA. Marillion is now able to proceed with its planned Phase 1 human clinical trial for the company’s lead product candidate, MN-201, an orally administered vitamin D5 analog for the treatment of cancer.
The Phase I trial will be an open-label, dose-escalation study to evaluate the safety and pharmacology of MN-201 in patients with advanced tumors in various cancers. The protocol for the clinical trial is currently before institutional review boards (IRBs) at the sites selected for the trial and clinical supplies are being prepared.
“MN-201 is the first synthetic vitamin D5 receptor ligand (VDRL) to be advanced into clinical trials for a variety of cancers including breast, prostate and colon cancers,” said Zahed Subhan, Ph.D, chief executive officer of Marillion Pharmaceuticals. “Based on a novel mechanism of action, MN-201 could have utility as both a monotherapy in the treatment of various malignancies and for use in combination with other chemotherapeutic agents where synergistic benefits may be possible,” added Dr. Subhan.
In preclinical studies, MN-201 demonstrated broad anti-tumor activity in cancer cells. In animal models, oral administration of MN-201 also resulted in anti-tumor activity including tumor regression in xenograft models of major solid tumor types. In contrast to treatment with other vitamin D(3) analogs and the naturally occurring vitamin D hormone, calcitriol, favorable anticancer effects with MN-201 were observed in the absence of significantly raised calcium levels.
| Translation - Chinese
Marillion制药公司今日宣布其新药研究申请(IND)已获得FDA的批准。Marillion是一家私营的新兴制药公司，主要开发治疗癌症、炎症和自身免疫疾病的新型药物。现在Marillion就可着手为其候选主打产品MN-201开展计划中的I期人临床试验。MN-201是一种治疗癌症的口服维生素D5类似物。
这项I期临床试验是一项开放性、剂量递增研究，旨在评估MN-201对患有各种晚期癌症患者的安全性和药理作用。目前伦理审查委员会正在审查入选该试验的单位的临床试验方案，同时临床试验用品也正在筹备当中。
Marillion制药公司的首席执行官Zahed Subhan博士称：“MN-201是首个进入临床试验的合成维生素D5受体配体(VDRL)，它用于治疗许多种癌症，其中包括乳癌、前列腺癌和结肠癌。”Subhan博士补充说，“由于采用了全新的作用机制，MN-201既可单独用于治疗各种恶性肿瘤，还可与其他化疗药物联合使用发挥协同效应”。
MN-201在临床前研究中的癌细胞上表现出广泛的抗肿瘤活性。口服MN-201在动物模型上同样表现出抗肿瘤活性，例如主要类型的实体瘤在异种移植模型上均出现了消退。与其他维生素D(3)类似物和天然维生素D激素骨化三醇不同的是，MN-201发挥其良好的抗癌活性时，钙水平并没有显著升高。 |
More Less | | Master's degree - Beijing Foreign Studies University | | Years of translation experience: 3. Registered at ProZ.com: Sep 2007. | | N/A | English to Chinese (Ministry of Education of PRC)
| | N/A | | Adobe Acrobat, Adobe Photoshop, Microsoft Excel, Microsoft Word, wordfast, Powerpoint, SDL TRADOS, SDLX, Wordfast | | CV will be submitted upon request | | calpain endorses ProZ.com's Professional Guidelines (v1.0). | | About me Master of Translation and Interpreting, Beijing Foreign Studies University;
Master of Science in Biology, Nanjing University.
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Keywords: biology, biochemsitry, medicine, medical, science, patent, paper, sci, translation, manuscript, proofreading, editing, 论文翻译，论文改写
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May 21 |
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