Working languages: Spanish to EnglishCatalan to EnglishEnglish (monolingual)
| Chris E
Geology + environment specialist PhD
Barcelona, Cataluña, Spain Local time: 17:38 CET (GMT+1)
Native in: English  | |
| Freelancer | | Translation, Editing/proofreading, Website localization, Voiceover (dubbing), Subtitling, Post-editing | | Specializes in: | | Geology | Environment & Ecology | | Genetics | Petroleum Eng/Sci | | Science (general) | Botany | | Zoology | Mining & Minerals / Gems | | Medical: Pharmaceuticals | Engineering (general) |
| Also works in: | | Agriculture | Forestry / Wood / Timber | | Livestock / Animal Husbandry | Materials (Plastics, Ceramics, etc.) | | Mechanics / Mech Engineering | Nuclear Eng/Sci | | Physics | Computers (general) | | Archaeology | Fisheries | | Finance (general) | Engineering: Industrial | | Anthropology | Astronomy & Space | | Aerospace / Aviation / Space | Biology (-tech,-chem,micro-) | | Business/Commerce (general) | Chemistry; Chem Sci/Eng | | Construction / Civil Engineering | Electronics / Elect Eng | | Meteorology |
More Less | | PRO-level points: 321, Questions answered: 113, Questions asked: 50 | Sample translations submitted: 1 Catalan to English: LINKER HISTONES NO EMPAQUETEN A L’ATZAR, INVESTIGADORS DEL CRG DEMOSTREN QUE TENEN LA SEVA FUNCIÓ ESPECÍFICA EN L’EMPAQUETAMENT DE L’ADN EN CROMATINA
General field: Science
Detailed field: Genetics | Source text - Catalan
LINKER HISTONES NO EMPAQUETEN A L’ATZAR, INVESTIGADORS DEL CRG DEMOSTREN QUE TENEN LA SEVA FUNCIÓ ESPECÍFICA EN L’EMPAQUETAMENT DE L’ADN EN CROMATINA
Investigadors del Centre de Regulació Genòmica (CRG) han descobert que les histones externes (linker histones) tenen un paper definit en la compactació de l’ADN en cromatina per a la formació dels cromosomes.
El treball, coordinat per Miguel Beato i fruit de la col·laboració entre investigadors d’Alemanya, Nova Zelanda i Espanya, es publicarà el dia 1 d’octubre a la prestigiosa revista científica PLoS ONE.
L’ADN es troba compactat en cromatina per a formar els cromosomes i les histones són les molècules encarregades de dur a terme aquesta compactació. Es coneixen diversos tipus d’histones i es classifiquen en Histones nuclears (core histones) o Histones externes (linker histones).
Fins ara, tots els subtipus d’histones externes (linker) s’havien considerat un element primordial per a la compactació de l’ADN en cromatina però no s’havia observat que podien tenir funcions específiques.
El treball liderat per Miguel Beato continua les troballes publicades anteriorment també per investigadors del CRG (M. Sancho et al. PLoS Genetics 4, e100227) que van observar, en cèl·lules de càncer de mama, que els subtipus d’histones linker exercien diferents funcions. Així, el treball que es publicarà dijous a PLoS ONE demostra el paper específic dels subtipus d’histones externes que poden tenir diferent afinitat per la cromatina i major o menor capacitat de compactació.
The work lead by Miguel Beato is a continuation of previously published work, also by researchers from the CRG (M. Sancho et al. PLoS Genetics 4, e100227) which observed that, in breast cancer cells, the subtypes of linker histones have different functions. The work which will be published on Thursday in PLoS ONE reveals the specific roles of the subtypes of linker histones which can have different affinities to chromatin
A més, en contra de la idea acceptada fins ara, l’estudi mostra com aquestes histones no impedeixen als remodeladors de cromatina dependents d’ATP la seva funció en la reorganització de la cromatina.
Aquest descobriment dóna noves pistes sobre els mecanismes de condensació de l’ADN en cromatina i demostra com els subtipus d’histones externes podrien classificar-se en: condensadors lleus, intermedis o forts. Alhora, obre la porta a nous estudis per a la comprensió dels mecanismes de conservació i organització del genoma al nucli. El genoma és el codi que determina les característiques biològiques dels éssers vius. La seqüència lineal de l’ADN dels nostres cromosomes fa més de 2 metres. Per allotjar tota aquesta informació en l’espai diminut del nucli cel·lular, cal empaquetar-la de forma molt eficient.
Per a l’estudi, els investigadors han utilitzat nucleosomes assemblats amb histones recombinants i minicromosomes que han analitzat amb mètodes bioquímics i amb un microscopi de força atòmica (AFM).
Glossari:
CROMATINA: Material genètic del nucli format per llarguíssimes molècules de DNA associades a d'altres substàncies, principalment histones, i que també conté proteïnes, RNA, enzims, ions, etc.
NUCLEOSOMA: Estructura esfèrica de la fibra de cromatina de les cèl·lules eucariotes, que conté vuit molècules d'histona i aproximadament dos-cents parells de bases de DNA.
| Translation - English
LINKER HISTONES DO NOT PACKAGE RANDOMLY, INVESTIGATORS FROM THE CRG DEMONSTRATE THAT THEY HAVE A SPECIFIC FUNCTION IN THE PACKAGING OF DNA IN CHROMATIN
Investigators from the Center for Genomic Regulation have discovered that linker histones have a definite role in the compaction of DNA in chromatin for the formation of chromosomes.
The work, coordinated by Miguel Beato and a result of the collaboration between researchers from Germany, New Zealand and Spain, will be published on the 1st of October in the prestigious scientific journal PLoS ONE.
DNA is found compacted in chromatin for the formation of chromosomes and histones are the molecules responsible for this compaction. Various types of histones are recognized and they are classified as core histones or linker histones.
To date, all the subtypes of linker histones had been considered to be primordial elements for the compaction of DNA in chromatin but they had not been observed to have specific functions.
The work lead by Miguel Beato is a continuation of previously published findings, also by researchers from the CRG (M. Sancho et al. PLoS Genetics 4, e100227), which observed that, in breast cancer cells, the subtypes of linker histones have different functions. The work, which will be published on Thursday in PLoS ONE, reveals the specific roles of the subtypes of linker histones that can have different affinities with chromatin and a greater or lesser compaction capacity.
Moreover, contrary to the currently accepted idea, the study shows that these histones do not impede the function of ATP-dependent chromatin remodelers in chromatin reorganization.
This discovery provides new clues about the condensation mechanisms of DNA in chromatin and demonstrates how the subtypes of linker histones can be classified as: weak, intermediate or strong condensers. At the same time the door is opened to new studies into the understanding of mechanisms for the conservation and organization of the genome in the nucleus. The genome is the code which determines the biological characteristics of living things. The linear sequence of the DNA in our chromosomes is more than 2 meters long. In order to put all of this information into the tiny nucleus of a cell, it is necessary to package it extremely efficiently.
For this study, the researchers used nucleosomes assembled with recombinant histones and minichromosomes which were analyzed using both biochemical methods and an atomic force microscope.
Glossary:
CROMATIN: Genetic material of the nucleus formed by very long molecules of DNA associated with other substances, principally histones, and which also contain proteins, RNA, enzymes, ions, etc.
NUCLEOSOME: Spherical structure of the chromatin fiber of eukaryotic cells, which contains eight histone molecules and approximately two hundred DNA base pairs.
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More Less | | Botany, Fluid dynamics, Geological Glossary - Chris E, Geotechnical glossary | | Years of translation experience: 7. Registered at ProZ.com: Nov 2008. | | N/A | | N/A | | N/A | | Adobe Acrobat, Adobe Illustrator, Adobe Photoshop, Dreamweaver, Microsoft Excel, Microsoft Word, Powerpoint | | http://www.busci.co.uk | | CV available upon request | | Chris E endorses ProZ.com's Professional Guidelines (v1.0). | | About me Chris Ellison
PhD qualified Geologist
PhD, BSc., CELTA
Corporate clients know that an
excellent translation enhances the quality of the science
by giving confidence to the reader in the work undertaken. Conversely, a poorly translated document, with
mistranslations or grammatical, spelling or punctuation errors, raises questions about the accuracy of the original science.
With over 14 years experience in working in the fields of geology and environmental science (Cambridge University, UCL)
Published in various scientific journals
Previously assistant editor of the Mineralogical Magazine (MinMag)
Contributor to various scientific publications
Specialist in Natural Sciences including:
Geology
Environmental Sciences
Botany
Biology
Zoology
Botany
Other fields of interest and experience:
Geotechnical Engineering
Engineering
Building
Chemistry
Physics
Agriculture
Multinational clients - references available
Recent projects include:
"LA CUEVA DE ALTAMIRA. 22.000 AÑOS DE HISTORIA" [article for publication]
"DESARROLLO DE UN SISTEMA DE INYECCIÓN DIRECTA DE GASOLINA PARA UN MOTOR ALTERNATIVO DE 2T." [article for publication]
""LINKER HISTONES NO EMPAQUETEN A L’ATZAR, INVESTIGADORS DEL CRG DEMOSTREN QUE TENEN LA SEVA FUNCIÓ ESPECÍFICA EN L’EMPAQUETAMENT DE L’ADN EN CROMATINA" [press release]
"DESCUBIERTA UNA PROTEÍNA IMPLICADA EN LA SORDERA" [press release]
""Geotechnical study for the construction of a 50 MW concentrating solar power plant in *********" [confidential report]
"Analytical Results of the 1st Groundwater Monitoring Round Conducted at the ********* Plant in ********" [confidential report]
Full CV available on request
(please state whether you need an ACADEMIC or SHORT version)
| This user has earned KudoZ points by helping other translators with PRO-level terms. Click point total(s) to see term translations provided.
Total pts earned: 321
(All PRO level)
| | Top languages (PRO) | | Spanish to English | 308 | | English to Spanish | 9 | | Catalan to English | 4 | | Top general fields (PRO) | | Science | 189 | | Tech/Engineering | 124 | | Other | 8 | | Top specific fields (PRO) | | Geology | 281 | | Environment & Ecology | 8 | | Engineering (general) | 8 | | Mining & Minerals / Gems | 8 | | Botany | 4 | | Construction / Civil Engineering | 4 | | Mechanics / Mech Engineering | 4 | | Pts in 1 more fld > |
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Keywords: geology, geologia, geological, environment, environmental, science, scientific, geotchnical, geotechnic, geotecnic, petroleum, oil, construction, biology, zoology, botany, report, paper, journal, editing, proof-reading, proof reading, translation, expert, quality, speed
Profile last updated
Mar 27, 2011 |
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