Genetics: frameshift
Thread poster: Emma Goldsmith

Emma Goldsmith  Identity Verified
Spain
Local time: 03:26
Member (2010)
Spanish to English
Jan 10, 2011

I am translating a glossary on genetics.
The explanation for the term "frameshift" is an insertion or deletion in a triplet reading frame or three letter codon that disrupts the frame.

The example (in Spanish) is a short sentence made up entirely of 3 letter words "HAY PAN CON AJO", which would shift to "HA YPA NCO NAJ O"

Can anyone tell me if there is a standard sentence in English to illustrate this concept, or can I use any one that takes my fancy?

Thank you in advance for your ideas.


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aradek  Identity Verified
United States
Local time: 20:26
Hungarian to English
+ ...
An example Jan 10, 2011

I am not aware of any standard example sentence, but here is one that I found:

Example:
Original Sentence- THE BIG DOG RAN AND HIT HIS ARM
Mutated Sentence- THE BAI GDO GRA NAN DHI THI SAR M
The sentence doesnt make sense because of the added A in BIG.


http://wiki.answers.com/Q/How_did_the_frameshift_mutation_affect_the_protein


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Joanne Archambault  Identity Verified
United States
Local time: 21:26
Member (2009)
French to English
frameshift mutation Jan 10, 2011

In the explanation, I would specify that the addition or deletion of the nucleotide shifts the reading frame during protein translation and results in an altered protein.

I think the best example sentence would be something that includes "frameshift mutation", such as found here:

- http://www.suite101.com/content/smallscale-genetic-dna-mutation-a54302
- http://en.wikipedia.org/wiki/Frameshift_mutation
- http://ghr.nlm.nih.gov/glossary=frameshiftmutation
- http://ghr.nlm.nih.gov/handbook/illustrations/frameshift --> very nice image here!

HTH,

Joanne

--------------------------------------------------------------------
Joanne Archambault, PhD (Biology)
FR > EN Translator specializing in Pharmaceuticals and Orthopedics


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Germaine  Identity Verified
Canada
Local time: 21:26
Member (2005)
English to French
+ ...
other examples Jan 10, 2011

In this article - http://www.genetichealth.com/g101_changes_in_dna.shtml -, the same sentence is used to illustrate a frame-shift mutation as well as deletion, insertion and inversion mutations: The fat cat ate the wee rat.

A variation is used in this book - http://www.ncbi.nlm.nih.gov/books/NBK21950/ : the fat cat ate the big rat.

This glossary - http://curecmd.org/resources/glossary - uses "the man has cat and hat" the same ways.


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Emma Goldsmith  Identity Verified
Spain
Local time: 03:26
Member (2010)
Spanish to English
TOPIC STARTER
Thank you Jan 10, 2011

Thank you Aradek, Joanne and Germaine for your helpful comments and links. I think I will make up my own example as there is no standard one in English.

It's great to have this medical forum to "meet" other people with different language pairs but the same speciality


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Genetics: frameshift

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