Actually, there's nothing wrong with the selection except that I have a client who wants me to follow his settings on the TM exactly, which had the Multiple Translations check box unchecked. So I thought whether selecting the check box will affect anything in his TM.
If it doesn't, then I'd just leave it as that.
This depends on how you return your work to your client. The typical reason for requiring specific settings is segmentation - the 'multiple TU' setting doesn't impact on that, nor will there be a problem if you return an uncleaned file.