imprint on the progression

Dutch translation: stempel drukt op de ontwikkeling

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:imprint on the progression
Dutch translation:stempel drukt op de ontwikkeling
Entered by: Charline Helsmoortel

18:07 Feb 3, 2011
English to Dutch translations [PRO]
Medical - Medical: Health Care / diabetes
English term or phrase: imprint on the progression
The preeminence of A1C as a better indicator of future complications, at least relative to fasting glucose (1,5), is in agreement with the concept of “metabolic memory,” which postulates that hyperglycemia leaves a very early imprint on the progression to complications.
Charline Helsmoortel
Belgium
Local time: 09:06
stempel drukt op de ontwikkeling
Explanation:
...... al heel vroeg een stempel drukt op de ontwikkeling van latere complicaties

'early imprint' houd verband met 'indicator' en het duidt op hoe de dingen zich gaan ontwikkelen: stempel drukt

--------------------------------------------------
Note added at 1 day8 hrs (2011-02-05 02:36:15 GMT)
--------------------------------------------------

'Hardnekkige en verkeerde aangeleerde celbiochemische gewoonten'

Ik heb wat bekeken over de 'metabolic memory'. In feite is het allemaal niet nieuw maar het begrip 'metabolic memory' bestaat in ieder geval nog niet zo lang als dat men onderzoek doet in deze richting. Dat is dus relatief nieuw.

Wat ermee wordt bedoeld, is dat de biochemie van de cel veranderd onder hypoglykemie en, nadat het bloedglucose op het juiste peil is gebracht, niet meteen, pas na lange tijd, of helemaal niet terugkeert naar de situatie van voor het optreden van de hyperglykemie.

M.a.w. woorden (perioden van) hyperglykemie (brengen)/brengt de celbiochemie uit balans en het kan lang duren (mogelijk hoe langer de hyperglykemie, hoe langer het duurt) voordat de cel is hersteld van die 'overdosering van glucose' ook al is die dosis al lang weer op het juiste niveau.

Je bent één keer de fout ingegaan maar voorlopig zit je nog wel met de gebakken peren: er zijn secundaire effecten opgetreden. Er is een klap uitgedeeld en die dreunt voorlopig nog wel even na.

Hoe langer de hyperglykemie duurt hoe meer de celbiochemie (blijvend) verziekt raakt en hoe moeilijker het wordt die nog terug te draaien.

En hoe eerder je begint met de glucose op het juiste peil te brengen hoe minder hardnekkig die 'verzieking' van de celbiochemie zal zijn.

(dit alles natuurlijk als we ervan uitgaan dat de theorie van het 'metabole geheugen' niet het voortbrengsel is van selectief wetenschappelijk onderzoek of een andere tekortkoming van de onbevooroordeeldheid; er bestaan ook meerdere opvattingen over wat het nou zou zijn, zo lijkt het, of verschillende interpretaties van lezers van één of een beperkt aantal theorieën :-))

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as ‘metabolic memory.’ Potential mechanisms for propagating this ‘memory’ are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this ‘metabolic memory’ suggests the need for very early aggressive treatment aiming to ‘normalize’ glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.

http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2007....

Peroxynitrite accumulation in the retinal microvasculature, the site of histopathology, fails to normalize after reversal of hyperglycemia, and superoxide remains inadequately scavenged. This failure of reversal of peroxynitrite accumulation could be, in part, responsible for the resistance of diabetic retinopathy to reverse after termination of PC.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906703/

This phenomenon has recently been defined as ‘Metabolic Memory.’ It was first hypothesized by Brownlee (Nature 2000), and since shown by many researchers that overproduction of free radicals, superoxide anion (O2−•) in particular, forms the unifying link between hyperglycemia and the complications of diabetes. It has also been shown that antioxidant molecules can at least partially reverse these complications both in the laboratory bench and clinically.

In this study we have confirmed in three different models (human endothelial cells, retinal cells and retina from diabetic animals) that, even normalizing glycemia, a persistent activation of many pathways involved in the pathogenesis of diabetic complications is still present. However, the major finding has been the demonstration that even normalizing glycemia an overproduction of free radicals is still evident and, overall, that inhibiting their production, particularly at the mitochondrial level, can switch off *the memory’ effect of hyperglycemia*.

These findings clearly open a new field of research, aiming to obtain specific compounds able of blocking the ‘Metabolic Memory’

http://www.endocrine-abstracts.org/ea/0020/ea0020s15.2.htm

As if struggling with normal memory overload isn’t enough, now we have to worry about dealing with metabolic memory? Well, the good news is that this has nothing to do with what your brain remembers – it’s all about the memory programmed into your veins when you first start having high blood sugar symptoms. Even after your diabetes symptoms are diagnosed and you get back to a normal blood sugar range, this effect continues to cause problems.

Some new research just published indicates that your veins remember the stress they experienced when you had high blood sugar levels of glycated hemoglobin. That’s the condition when sugar molecules attach themselves to the outside of your red blood cells because your body can’t use insulin to get the energy from the sugar out of the blood and into your organs, muscles and other tissues.

Even if your diabetes control can reduce blood sugar back to normal glucose levels, your microvascular system can continue to signal the body that it’s still under stress. We don’t have all the answers yet, but it appears to be related to the inflammation caused by what I call the rust effect – the glycated hemoglobin trying to muscle its way through the tiny veins, even though there’s really not enough room for the extra molecule of attached sugar.

[deze opvatting gaat uit van een mechanisch effect … ]

So far, it looks like the best way to relieve this metabolic memory is to get back to a normal blood sugar level as soon as possible, so there’s less of this kind of damage to begin with. This means that early diagnosis is even more important than ever, as well as doing everything possible to reduce blood sugar as quickly as you can.


--------------------------------------------------
Note added at 1 day8 hrs (2011-02-05 02:40:29 GMT)
--------------------------------------------------

.... biochemie van de cel veranderd onder hypoglykemie ....
'hypoglykemie' moet natuurlijk 'hyperglykemie zijn

--------------------------------------------------
Note added at 1 day9 hrs (2011-02-05 03:20:25 GMT)
--------------------------------------------------

de hyperglykemie komt natuurlijk doordat de glucose niet uit het bloed kan worden opgenomen (door cellen die daar wel behoefte aan hebben):

If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect so that glucose will not be absorbed properly by those body cells that require it nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.

--------------------------------------------------
Note added at 1 day9 hrs (2011-02-05 03:47:25 GMT)
--------------------------------------------------

"voordat de cel is hersteld van die 'overdosering van glucose'

in wezen had ik dus moeten zeggen 'voordat de cel is hersteld van die 'onderdosering van glucose'

de glucose wordt op peil gebracht doordat het weer de cellen in kan onder invloed van insuline (diabetes type 1)

die cellen zwemmen wel in de glucose maar alleen maar omdat het niet die cellen in kan
Selected response from:

Barend van Zadelhoff
Netherlands
Local time: 09:06
Grading comment
Bedankt!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +1invloed op de ontwikkeling
Michiel Leeuwenburgh
3een spoor vastlegt voor de latere ontwikkeling
Lianne van de Ven
3stempel drukt op de ontwikkeling
Barend van Zadelhoff


Discussion entries: 2





  

Answers


14 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
een spoor vastlegt voor de latere ontwikkeling


Explanation:
De superieure geschiktheid van A1C als een betere indicator voor complicaties in de toekomst, vergeleken althans met de nuchtere glucosespiegel (1,5), is in overeenstemming met het concept van het 'metabolisch geheugen' dat postuleert dat hyperglycemie al vroeg een spoor vastlegt voor de latere ontwikkeling van complicaties.

Ik kan geen referenties vinden voor de vertaling van metabolisch geheugen, maar dat lijkt me hier geen probleem.

Lianne van de Ven
United States
Local time: 04:06
Specializes in field
Native speaker of: Native in DutchDutch
PRO pts in category: 6
Login to enter a peer comment (or grade)

13 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
invloed op de ontwikkeling


Explanation:
Volgens mij kun je het prima hierop houden.
"... dat hyperglycemie (of hyperglykemie) een zeer vroege invloed heeft op de ontwikkeling van complicaties."
Dat lijkt mij duidelijk genoeg.

Michiel Leeuwenburgh
Netherlands
Local time: 09:06
Native speaker of: Native in DutchDutch
PRO pts in category: 20

Peer comments on this answer (and responses from the answerer)
agree  Monique Zwanenburg Widingsjö
2 hrs
  -> Dankjewel!
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22 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
stempel drukt op de ontwikkeling


Explanation:
...... al heel vroeg een stempel drukt op de ontwikkeling van latere complicaties

'early imprint' houd verband met 'indicator' en het duidt op hoe de dingen zich gaan ontwikkelen: stempel drukt

--------------------------------------------------
Note added at 1 day8 hrs (2011-02-05 02:36:15 GMT)
--------------------------------------------------

'Hardnekkige en verkeerde aangeleerde celbiochemische gewoonten'

Ik heb wat bekeken over de 'metabolic memory'. In feite is het allemaal niet nieuw maar het begrip 'metabolic memory' bestaat in ieder geval nog niet zo lang als dat men onderzoek doet in deze richting. Dat is dus relatief nieuw.

Wat ermee wordt bedoeld, is dat de biochemie van de cel veranderd onder hypoglykemie en, nadat het bloedglucose op het juiste peil is gebracht, niet meteen, pas na lange tijd, of helemaal niet terugkeert naar de situatie van voor het optreden van de hyperglykemie.

M.a.w. woorden (perioden van) hyperglykemie (brengen)/brengt de celbiochemie uit balans en het kan lang duren (mogelijk hoe langer de hyperglykemie, hoe langer het duurt) voordat de cel is hersteld van die 'overdosering van glucose' ook al is die dosis al lang weer op het juiste niveau.

Je bent één keer de fout ingegaan maar voorlopig zit je nog wel met de gebakken peren: er zijn secundaire effecten opgetreden. Er is een klap uitgedeeld en die dreunt voorlopig nog wel even na.

Hoe langer de hyperglykemie duurt hoe meer de celbiochemie (blijvend) verziekt raakt en hoe moeilijker het wordt die nog terug te draaien.

En hoe eerder je begint met de glucose op het juiste peil te brengen hoe minder hardnekkig die 'verzieking' van de celbiochemie zal zijn.

(dit alles natuurlijk als we ervan uitgaan dat de theorie van het 'metabole geheugen' niet het voortbrengsel is van selectief wetenschappelijk onderzoek of een andere tekortkoming van de onbevooroordeeldheid; er bestaan ook meerdere opvattingen over wat het nou zou zijn, zo lijkt het, of verschillende interpretaties van lezers van één of een beperkt aantal theorieën :-))

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as ‘metabolic memory.’ Potential mechanisms for propagating this ‘memory’ are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this ‘metabolic memory’ suggests the need for very early aggressive treatment aiming to ‘normalize’ glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.

http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2007....

Peroxynitrite accumulation in the retinal microvasculature, the site of histopathology, fails to normalize after reversal of hyperglycemia, and superoxide remains inadequately scavenged. This failure of reversal of peroxynitrite accumulation could be, in part, responsible for the resistance of diabetic retinopathy to reverse after termination of PC.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906703/

This phenomenon has recently been defined as ‘Metabolic Memory.’ It was first hypothesized by Brownlee (Nature 2000), and since shown by many researchers that overproduction of free radicals, superoxide anion (O2−•) in particular, forms the unifying link between hyperglycemia and the complications of diabetes. It has also been shown that antioxidant molecules can at least partially reverse these complications both in the laboratory bench and clinically.

In this study we have confirmed in three different models (human endothelial cells, retinal cells and retina from diabetic animals) that, even normalizing glycemia, a persistent activation of many pathways involved in the pathogenesis of diabetic complications is still present. However, the major finding has been the demonstration that even normalizing glycemia an overproduction of free radicals is still evident and, overall, that inhibiting their production, particularly at the mitochondrial level, can switch off *the memory’ effect of hyperglycemia*.

These findings clearly open a new field of research, aiming to obtain specific compounds able of blocking the ‘Metabolic Memory’

http://www.endocrine-abstracts.org/ea/0020/ea0020s15.2.htm

As if struggling with normal memory overload isn’t enough, now we have to worry about dealing with metabolic memory? Well, the good news is that this has nothing to do with what your brain remembers – it’s all about the memory programmed into your veins when you first start having high blood sugar symptoms. Even after your diabetes symptoms are diagnosed and you get back to a normal blood sugar range, this effect continues to cause problems.

Some new research just published indicates that your veins remember the stress they experienced when you had high blood sugar levels of glycated hemoglobin. That’s the condition when sugar molecules attach themselves to the outside of your red blood cells because your body can’t use insulin to get the energy from the sugar out of the blood and into your organs, muscles and other tissues.

Even if your diabetes control can reduce blood sugar back to normal glucose levels, your microvascular system can continue to signal the body that it’s still under stress. We don’t have all the answers yet, but it appears to be related to the inflammation caused by what I call the rust effect – the glycated hemoglobin trying to muscle its way through the tiny veins, even though there’s really not enough room for the extra molecule of attached sugar.

[deze opvatting gaat uit van een mechanisch effect … ]

So far, it looks like the best way to relieve this metabolic memory is to get back to a normal blood sugar level as soon as possible, so there’s less of this kind of damage to begin with. This means that early diagnosis is even more important than ever, as well as doing everything possible to reduce blood sugar as quickly as you can.


--------------------------------------------------
Note added at 1 day8 hrs (2011-02-05 02:40:29 GMT)
--------------------------------------------------

.... biochemie van de cel veranderd onder hypoglykemie ....
'hypoglykemie' moet natuurlijk 'hyperglykemie zijn

--------------------------------------------------
Note added at 1 day9 hrs (2011-02-05 03:20:25 GMT)
--------------------------------------------------

de hyperglykemie komt natuurlijk doordat de glucose niet uit het bloed kan worden opgenomen (door cellen die daar wel behoefte aan hebben):

If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect so that glucose will not be absorbed properly by those body cells that require it nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.

--------------------------------------------------
Note added at 1 day9 hrs (2011-02-05 03:47:25 GMT)
--------------------------------------------------

"voordat de cel is hersteld van die 'overdosering van glucose'

in wezen had ik dus moeten zeggen 'voordat de cel is hersteld van die 'onderdosering van glucose'

de glucose wordt op peil gebracht doordat het weer de cellen in kan onder invloed van insuline (diabetes type 1)

die cellen zwemmen wel in de glucose maar alleen maar omdat het niet die cellen in kan

Barend van Zadelhoff
Netherlands
Local time: 09:06
Specializes in field
Native speaker of: Native in DutchDutch
PRO pts in category: 46
Grading comment
Bedankt!
Login to enter a peer comment (or grade)



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