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lethal factor N-terminus (LFN)

Russian translation: N-концевой домен летального фактора (LFN)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:lethal factor N-terminus (LFN)
Russian translation:N-концевой домен летального фактора (LFN)
Entered by: Nitrogen

17:45 Nov 3, 2017
English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-) / иммунология
English term or phrase: lethal factor N-terminus (LFN)
In certain embodiments, disclosed herein are methods of conditioning a subject for engraftment, such methods comprising selectively depleting or ablating an endogenous stem cell population in a target tissue (e.g., bone marrow tissue) of the subject by: (a) administering to the subject an effective amount of a pore-forming chimera comprising a mutant protective antigen (mut-PA) coupled (e.g., functionally coupled) to an agent, and thereby forming one or more pores in the cell membrane of the endogenous stem cell population; and (b) administering to the subject an effective amount of a second chimera, wherein the second chimera comprises a factor (e.g., an enzymatic factor) coupled to a toxin, wherein the factor is selected from the group consisting of ***lethal factor N-terminus (LFN)***, edema factor N-terminus (EFN) or fragments thereof, and wherein the toxin is internalized by the endogenous stem cell population, thereby selectively depleting or ablating the endogenous stem cell population in the target tissue and conditioning the subject for engraftment.

Спасибо!
Nitrogen
Local time: 02:20
N-концевой домен летального фактора (LFN)
Explanation:
http://www.antibiotic.ru/cmac/2002_4_2/full/104.htm
Летальный фактор (ЛФ) является цинкзависимой протеазой, имеет сложную химическую структуру и состоит из 4 доменов, каждый из которых выполняет специфическую функцию [26].

http://www.dslib.net/molekula/letalnyj-faktor-iz-bacillus-an...
ОФ состоит из N-концевого ПА-связывающего домена, центрального каталитического домена и С-концевого спирального домена [22, 23] (рис. 1В). N-концевой домен гомологичен по структуре и функциям 1 домену ЛФ [16].
Selected response from:

Oleksandr Mandzhos
Ukraine
Grading comment
Большое спасибо за ссылки!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1N-концевой домен летального фактора (LFN)
Natalie
4N-концевой домен летального фактора (LFN)
Oleksandr Mandzhos


  

Answers


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
lethal factor n-terminus (lfn)
N-концевой домен летального фактора (LFN)


Explanation:
Летальный фактор - это эффекторная субъединица токсина (сибирской язвы, например)

Natalie
Poland
Local time: 01:20
Specializes in field
Native speaker of: Russian
PRO pts in category: 4329

Peer comments on this answer (and responses from the answerer)
agree  Oleksandr Mandzhos: сам виноват, долго выбирал ссылки...
1 hr
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1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5
lethal factor N-terminus (lfn)
N-концевой домен летального фактора (LFN)


Explanation:
http://www.antibiotic.ru/cmac/2002_4_2/full/104.htm
Летальный фактор (ЛФ) является цинкзависимой протеазой, имеет сложную химическую структуру и состоит из 4 доменов, каждый из которых выполняет специфическую функцию [26].

http://www.dslib.net/molekula/letalnyj-faktor-iz-bacillus-an...
ОФ состоит из N-концевого ПА-связывающего домена, центрального каталитического домена и С-концевого спирального домена [22, 23] (рис. 1В). N-концевой домен гомологичен по структуре и функциям 1 домену ЛФ [16].

Oleksandr Mandzhos
Ukraine
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 36
Grading comment
Большое спасибо за ссылки!
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