"fully powered trials"

Spanish translation: pruebas plenamente validas

14:31 Oct 28, 2019
English to Spanish translations [PRO]
Medical - Mathematics & Statistics / Clinical trials
English term or phrase: "fully powered trials"
Hi all,

I'm having trouble understanding and translating "fully powered" in the following sentence:

"these were three fully powered studies with more than xx patients each"

Your insight would be greatly appreciated :)

Thanks!
Andrea Riffo
Chile
Local time: 10:55
Spanish translation:pruebas plenamente validas
Explanation:
https://expansion.mx/expansion/2011/09/14/xes-el-que-buscan
Selected response from:

Juan Arturo Blackmore Zerón
Mexico
Local time: 08:55
Grading comment
Es lo más cercano, me ayudó a llegar a "pruebas con potencia (estadística, se entiende) suficiente"

¡Gracias!
3 KudoZ points were awarded for this answer



Summary of answers provided
3pruebas estadísticas completas
Juan Gil
2ensayos de poder estadistico total
Neil Ashby
3 -1pruebas plenamente validas
Juan Arturo Blackmore Zerón
Summary of reference entries provided
Refs.
Taña Dalglish

Discussion entries: 4





  

Answers


15 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5
ensayos de poder estadistico total


Explanation:
https://www.elsevier.es/es-revista-revista-medica-clinica-la...

"El complemento 1- β representa la probabilidad de observar en la muestra una determinada diferencia o efecto y es a lo que se llama el poder estadístico o potencia del estudio."

I'm not sure how "fully" would be expressed in Spanish.
I know that it is reported as a %, for example:

https://www.fisterra.com/mbe/investiga/poder_estadistico/pod...
"Cálculo del poder estadístico de un estudio
Así, puede concluirse que de haber estudiado 130 pacientes por grupo, se obtiene una potencia de sólo el 36.6% para detectar una diferencia mínima del 10%, una potencia del 68% para detectar una diferencia del 15% y de un 90.2% para una diferencia del 20%. Este tipo de gráficos resulta muy útil tanto en la fase de diseño de un estudio como a la hora de valorar a posteriori el poder de una investigación.


So maybe "ensayos de 100% poder estadistico / potencia estadistica"

Neil Ashby
Spain
Local time: 14:55
Works in field
Native speaker of: English
PRO pts in category: 4
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2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
pruebas estadísticas completas


Explanation:
"Determining the optimal sample size for a study assures an adequate power to detect statistical significance. Hence, it is a critical step in the design of a planned research protocol. Using too many participants in a study is expensive and exposes more number of subjects to procedure. Similarly, if study is underpowered, it will be statistically inconclusive and may make the whole protocol a failure. This paper covers the essentials in calculating power and sample size for a variety of applied study designs. Sample size computation for single group mean, survey type of studies, 2 group studies based on means and proportions or rates, correlation studies and for case-control for assessing the categorical outcome are presented in detail."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409926/

"Based on these factors, the study must have an adequate sample size, relative to the goals and the possible variabilities of the study. Sample must be ‘big enough’ such that the effect of expected magnitude of scientific significance, to be also statistically significant. Same time, It is important that the study sample should not be ‘too big’ where an effect of little scientific importance is nevertheless statistically detectable. In addition, sample size is important for economic reasons: An under-sized study can be a waste of resources since it may not produce useful results while an over-sized study uses more resources than necessary. In an experiment involving human or animal subjects, sample size is a critical ethical issue. Since an ill-designed experiment exposes the subjects to potentially harmful treatments without advancing knowledge."

these were three fully powered studies with more than xx patients each: estos fueron tres estudios estadísticos completos con mas de xx pacientes en cada uno

Juan Gil
Venezuela
Local time: 09:55
Native speaker of: Native in SpanishSpanish
PRO pts in category: 32
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6 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
pruebas plenamente validas


Explanation:
https://expansion.mx/expansion/2011/09/14/xes-el-que-buscan

Juan Arturo Blackmore Zerón
Mexico
Local time: 08:55
Native speaker of: Spanish
PRO pts in category: 15
Grading comment
Es lo más cercano, me ayudó a llegar a "pruebas con potencia (estadística, se entiende) suficiente"

¡Gracias!

Peer comments on this answer (and responses from the answerer)
disagree  Neil Ashby: Your ref and suggestion has nothing to do with statistics.
15 days
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Reference comments


13 mins
Reference: Refs.

Reference information:
HIV Integrase inhibitors - ASX
www.asx.com.au › asxpdf › pdf
Nov 24, 2014 - Three separate **fully powered clinical studies** discussed at the 20th International AIDS Conference in Melbourne. • Compared treatment based ...

Clinical Trial: Early Psychological Intervention to Prevent ...
https://trials.trialscout.com › clinical-trial-details › early-psychological-inter...
Descriptive statistics will be used to understand the feasibility of testing the written exposure therapy intervention as part of a larger, **fully powered clinical trial.**

Sample sizes in CTs: truth seeking - CEBM
https://www.cebm.net › truth-seeking-sample-sizes-in-clinical-trials
Sep 21, 2018 - “The average power of a clinical trial is only 9%, according to a recent ... asking a funder to commit to the huge cost of a fully-powered trial.

On participatory research and building the evidence base ...
https://dart.ed.ac.uk › Blog › Autism
Oct 8, 2018 - The project is a multi-site fully-powered clinical trial of a new manualised .... **It's built on a theoretical model and broad range of evidence that ...**

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Note added at 15 mins (2019-10-28 14:46:48 GMT)
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Enfermedades Raras - Cursos de Enfermería
www.isfie.org › documentos › er-retos-y-oportunidades-libro
desafío de diseñar un ensayo clínico para una enfermedad tan rara. El desarrollo de ...... ****denominados estudios de gran potencia. *** Tradicionalmente, los ...

Taña Dalglish
Jamaica
Native speaker of: English
PRO pts in category: 23
Note to reference poster
Asker: Thank you. It would seem from the 3rd link that fully powered = adequately powered for *all* trial outcomes. I'll keep searching.

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