gene silencing

Catalan translation: silenciament genètic

English term or phrase:gene silencing
Catalan translation:silenciament genètic

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14:00 Feb 9, 2010
English to Catalan translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics
English term or phrase: gene silencing
Definition from MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Example sentence(s):
  • Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms.
  • The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
  • In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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silenciament genètic
Procés durant el qual un gen no s'expressa.
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Marià Pitarque
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Summary of translations provided
5 +4silenciament genètic
Marià Pitarque


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10 days   confidence: Answerer confidence 5/5 peer agreement (net): +4
silenciament genètic

Definition from Termcat:
Procés durant el qual un gen no s'expressa.

Example sentence(s):
  • D'altra banda, ARN petits, de tant sols uns 21-22 nucleòtids de llargada, també poden regular l'expressió de gens. Alguns d'aquests ARN actuen sobre regions del trànscrit madur d'un gen abans de la subseqüent síntesi de proteïna, aconseguint silenciar el gen. Mecanisme conegut com silenciament genètic postranscripcional o PTGS. - UPF  
  • El treball dels científics de l’ICO Girona no acaba aquí. Mitjançant l’ús de fàrmacs experimentals i tècniques de silenciament genètic han demostrat que la inhibició de l’autofàgia fa que les cèl·lules resistents es tornin sensibles al trastuzumab de nou. - ICO  
Marià Pitarque
Local time: 13:46
Native speaker of: Native in CatalanCatalan
PRO pts in category: 4

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Marc Figueras
132 days

Yes  Oriol Vives
1564 days

Yes  rostoll
1564 days

Yes  Marta Cervera Areny
1564 days
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