07:32 Mar 29, 2018
English to Chinese translations [PRO]
Science - Biology (-tech,-chem,micro-)
English term or phrase: species
Main, acidic, and basic species represent charge isoforms commonly detected in mAbs (Harris et al., 2001, Johnson et al., 2007, Liu et al., 2008) and originate mostly through posttranslational modifications of the amino acid backbone.

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United States
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Summary of answers provided
Yuemin Chen



3 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5

For your reference only.

This article focuses on characterization of acidic and basic species separated by chromatography techniques and includes information on charge heterogeneity reported since the publication of two reviews in 2008
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499298/

In this work, the adsorption behavior of the different charge isoforms of the same monoclonal antibody (mAb) on strong cation‐exchange resins is analyzed.
Link: https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.2017001...

Yuemin Chen
Local time: 12:11
Native speaker of: Native in ChineseChinese
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