human ether-a-go-go related gene
Chinese translation: hERG基因
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| 13:16 Oct 14, 2012 |
| English to Chinese translations [PRO] Medical - Medical: Pharmaceuticals / Clinical trials | |||||||
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|  Selected response from: Xiedong Lei China Local time: 17:20 | ||||||
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| 3 +1 | 人类钾通道基因 |
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| 4 | hERG基因 |
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Answers
8 mins confidence: 
peer agreement (net): +1
peer agreement (net): +1人类钾通道基因 Explanation: 可用hERG缩写 http://en.wikipedia.org/wiki/HERG hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K+) ions out of the muscle cells of the heart (cardiac myocytes), and this current is critical in correctly timing the return to the resting state (repolarization) of the cell membrane during the cardiac action potential.[2] Sometimes, when referring to the pharmacological effects of drugs, the terms "hERG channels" and IKr are used interchangeably, but, in the technical sense, "hERG channels" can be made only by scientists in the laboratory; in formal terms, the naturally-occurring channels in the body that include hERG are referred to by the name of the electrical current that has been measured in that cell type, so, for example, in the heart, the correct name is IKr. This difference in nomenclature becomes clearer in the controversy as to whether the channels conducting IKr include other subunits (e.g., beta subunits[5]) or whether the channels include a mixture of different types (isoforms) of hERG,[6] but, when the originally-discovered form of hERG[7] is experimentally transferred into cells that previously lacked hERG (i.e., heterologous expression), a potassium ion channel is formed, and this channel has many signature features of the cardiac 'rapid' delayed rectifier current (IKr),[8][9][10] including IKr's inward rectification that results in the channel producing a 'paradoxical resurgent current' in response to repolarization of the membrane.[11] |
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3 hrs confidence:
hERG基因 Explanation: hERG的全称是human ether-a-go-go related gene。它是从人的海马神经中分离出来的基因。hERG基因编码形成电压激活延迟内向整流的钾离子通道（Ikr）,大量分布在人的神经系统和心脏组织中。hERG 通道电流是心脏动作电位Ⅲ期复极化延迟整流的快相成分。在心肌细胞中，hERG 通道往往不是单独表达的，而是有组成孔道的α亚基及起调节作用的β亚基（KCNE2）共同表达。 遗传性长QT综合征（LQTS）是一种遗传性心脏病，临床特征表现为体表心电图QT 间隔延长，易发生室性心动过速、室颤及心脏骤停，有较高的心源猝死的危险。遗传学的研究已发现至少8种不同的长QT 综合征（LQT1-LQT8）。这些不同的长QT综合征分别与不同的基因相关。hERG基因的缺陷或突变通常导致LQT2（主要表现为低钾血）。KCNE2的缺陷与LQT6 相关。对引起遗传性长QT 综合征的hERG基因突变的结构和功能研究，对我们搞清楚致病机制及研发新的心脏病药物有重要意义。 人心肌细胞上的延迟整流钾电流(IKr)通道蛋白是由人ether-a-go-go-related基因(hERG)编码的。研究证实，hERG功能缺失以及化合物抑制IKr都会延长QT间期，并可能诱发尖端扭转型室性心动过速(Torsades de Pointes , TdP)，导致致命性心律失常。FDA和EMEA等管理机构要求，研究中的新药(IND)申报临床试验前需要进行hERG/IKr安全性评价。据统计，25-40%的先导化合物都显示出不同程度的hERG相关毒性。因此，候选药物的hERG安全性检测在药物开发过程中至关重要。金斯瑞的hERG安全性检测服务可为客户提供药物早期发现和临床前研究阶段的安全性评价，加速您的新药研发进程。 -------------------------------------------------- Note added at 3 hrs (2012-10-14 16:44:57 GMT) -------------------------------------------------- sanguinetti mc, jiang c, curran me, keating mt. a mechanistic link between an inherited and an acquired cardiac arrhythmia: herg encodes the i potassium channel.kr cell. 1995;81:299-307. http://fss.365heart.com/ziwang_html/html-wz/2011/09/temp_618... |
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