tree gatekeeping procedure

Dutch translation: poortwachtersprocedure met boomstructuur

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:tree gatekeeping procedure
Dutch translation:poortwachtersprocedure met boomstructuur
Entered by: Katrien De Clercq

10:58 Jan 30, 2015
English to Dutch translations [PRO]
Mathematics & Statistics / Klinische onderzoeken
English term or phrase: tree gatekeeping procedure
"The Bonferonni statistic is part of a tree gatekeeping procedure used to maintain strong control of the type I error rate in testing hypotheses among the primary and secondary efficacy endpoints."

Ik heb geen enkel idee hoe ik "tree gatekeeping procedure" moet vertalen. Heb het ook nog nooit aangetroffen in deze context. Kan iemand me hierbij helpen?
Katrien De Clercq
Local time: 17:03
"gatekeeper"/"poortwachter" procedure
Explanation:
I think it needs an explanatory note. I'd be inclined to keep the English word "gatekeeper" (in quotes) - professionals will understand it. "poortwachter" may be misleading as it's so much associated with clinical practice.

You could maybe literally translate "a Dmitrienko-style gatekeeping procedure"?
Selected response from:

DLyons
Ireland
Local time: 16:03
Grading comment
I did indeed keep de 'poortwachter' structure. Thank you!
2 KudoZ points were awarded for this answer



Summary of answers provided
2 +1"gatekeeper"/"poortwachter" procedure
DLyons
Summary of reference entries provided
tree gatekeeping
Lianne van de Ven
gatekeeping procedure
Barend van Zadelhoff

Discussion entries: 8





  

Answers


1 hr   confidence: Answerer confidence 2/5Answerer confidence 2/5 peer agreement (net): +1
"gatekeeper"/"poortwachter" procedure


Explanation:
I think it needs an explanatory note. I'd be inclined to keep the English word "gatekeeper" (in quotes) - professionals will understand it. "poortwachter" may be misleading as it's so much associated with clinical practice.

You could maybe literally translate "a Dmitrienko-style gatekeeping procedure"?

DLyons
Ireland
Local time: 16:03
Specializes in field
Native speaker of: English
PRO pts in category: 10
Grading comment
I did indeed keep de 'poortwachter' structure. Thank you!

Peer comments on this answer (and responses from the answerer)
agree  Barend van Zadelhoff: no references / I can't find 'gatekeeper' nor 'poortwachter' in Dutch literature in this field. // Ik stel voor: 'boomgestructureerde gatekeepingprocedure'
11 hrs
  -> Thanks Barend. There certainly aren't any online and there may be none at all. That's why I'm recommending quotes and/or English.
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Reference comments


4 hrs peer agreement (net): +1
Reference: tree gatekeeping

Reference information:
Hierin wordt het allemaal uitgelegd.
A Mixture Gatekeeping Procedure Based on the
Hommel Test for Clinical Trial Applications
http://www.multxpert.com/doc/bxdt2011.pdf

Lianne van de Ven
United States
Native speaker of: Native in DutchDutch

Peer comments on this reference comment (and responses from the reference poster)
agree  DLyons: Yes, Hommel has extensions to Dmitienko's original procedure. They may or may not apply in this case. Using just "Dmitrienko-style" is safe.
16 hrs
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1 day 6 hrs peer agreement (net): +1
Reference: gatekeeping procedure

Reference information:
3 soorten gatekeeping procedures

- parallel
- serial
- tree-structured

tree-structured is een uitbreiding op 'parallel' en 'serial':

Tree gatekeeping procedures
Efficient way to account for hierarchically ordered multiple objectives in clinical trials.
Extend serial and parallel gatekeeping methods

http://www.bassconference.org/PDFs/BASS 2006 Dmitrienko et a...

It is becoming increasingly common to consider designs with multiple endpoints, analyses and objectives in registration studies because additional information on the efficacy and safety profiles of an experimental drug helps patients, prescribing physicians and payers better understand its properties. More complicated study designs give rise to more sophisticated analysis methods. In the area of multiple comparisons, these problems motivated research on novel testing strategies for hierarchically ordered objectives.

This paper gives an overview of recent developments in this area with emphasis on testing strategies for multiple families of analyses.
The analyses are often related to multiple endpoints (both primary and secondary) but can also represent dose–control comparisons, noninferiority and superiority tests or inferences at several time points. Testing strategies considered here are commonly referred to as gatekeeping strategies. This terminology highlights the fact that the families of analyses are examined sequentially and each one serves as a gatekeeper for the subsequent families. The sequential testing approach reflects the hierarchical nature of the problem and improves the power of the more important analyses placed early in the sequence.

The paper is organized as follows. Section 2 introduces the basic concepts about gatekeeping and establishes notation. Section 3 describes serial gatekeeping procedures and Section 4 describes parallel gatekeeping procedures. A generalization of the two approaches, termed the tree gatekeeping approach, is considered in Section 5.
Tree gatekeeping procedures enable clinical trial researchers to construct testing strategies that combine serial and parallel gatekeepers and also account for logical restrictions among multiple analyses conducted in a clinical trial.

http://users.iems.northwestern.edu/~ajit/papers/40) Gatekeep...

'gatekeeping procedures' zijn gerelateerd aan het 'multiple comparions problem' (zie boven; in het Nederlands 'kanskapitalisatie') --> :

In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values

http://en.wikipedia.org/wiki/Multiple_comparisons_problem

In Dutch: kanskapitalisatie

http://nl.wikipedia.org/wiki/Kanskapitalisatie

Er zijn vele correctiemethoden voor kanskapitalisatie. Een bekende methode is de Bonferroni-correctie.

http://nl.wikipedia.org/wiki/Kanskapitalisatie

De Bonferroni-correctie (of Bonferroni-procedure) is een statistische methode ter bestrijding van het probleem van kanskapitalisatie.

http://nl.wikipedia.org/wiki/Bonferroni-correctie


Wanneer moet ik corrigeren voor multiple testing?

http://os1.amc.nl/wikistatistiek/index.php?title=Multiple_te...


gatekeeping procedure

http://www.proz.com/kudoz/english_to_dutch/medical_general/4...

Barend van Zadelhoff
Netherlands
Native speaker of: Native in DutchDutch
PRO pts in category: 24

Peer comments on this reference comment (and responses from the reference poster)
agree  DLyons: Yes, there's one hit!
20 mins
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