08:50 Sep 15, 2019
English to Dutch translations [PRO]
Medical - Medical (general)
English term or phrase: proteinogram
Hi, I cannot find the word in Dutch.
It is about medical research / check-up, epicrisis about kidney.

Thank you very much in advance.

Summary of answers provided
4 +1eiwitspectrum
Barend van Zadelhoff

Discussion entries: 1



5 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1

Eiwitspectrum (ESP)
Een eiwitelectroforese geeft een indruk van de relatieve verhouding tussen de verschillende eiwitcomponenten in het serum. Door middel van een eiwitelectroforese kan monoklonale gammopathie als gevolg van een maligniteit, autoimmuunziekte, inflammatoir proces of een andere aandoening aan het licht komen.

De eiwitten die in het serum voorkomen kunnen worden gescheiden in verschillende fracties, zodat een eiwitspectrum (ESP) ontstaat. De eiwitten worden op grond van hun lading en grootte gescheiden in albumine, alfa-1, alfa-2, beta- en gammaglobulinen.
Extra banden kunnen een aanwijzing zijn voor de aanwezigheid van één specifieke soort immunoglobuline (monoklonaal immunoglobuline) in een hoge concentratie, ook wel M-proteïne genoemd. M-proteïnen (Mpr) bevinden zich als een band in het normaliter diffuse gamma-gebied en liggen soms verstopt in het beta- of zelfs alfa-1,2 gebied.

Electrophoresis is designed to separate serum protein into different fractions, and it is the result of serum exposing to an electrical current allowing obtain the different serum proteins which migrate in bands, separating and quantifying the different fractions in a sample, according to their physical properties, such as size, charge and molecular weight (Eckersal 2008), the proteinogram in domestic animals considers the following fractions: albumin, alpha (α) globulin (α1, α2), beta (β) globulin (β1, β2), and gamma (γ) globulin (Thomas 2000, Meyer, Harvey 2004, Eckersal 2008).

Note added at 2 days 6 hrs (2019-09-17 15:36:56 GMT)

Protein electrophoresis - serum

Biomnis code


• Proteinogram
• Proteins - electrophoresis
• Proteinogram

Clinic significance

This test resolves albumin, apha-1 globulins, alpha-2 globulins, beta-globulins and gamma-globulins. With respect to the latter species: a low level might indicate primary deficiency or deficiency secondary to multiple myeloma with Bence Jones proteinuria; a high level of polyclonal immunoglobulin might indicate infectious or autoimmune disease; a high level of a monoclonal immunoglobulin might indicate malignant plasma cell dyscrasia like Waldenström's macroglobulinemia or a benign gammopathy of the elderly; finally, a high level of oligoclonal immunoglobulin is typical of certain infections. Measurement of the separated protein fractions can yield valuable information on a variety of conditions associated with changes in the individual protein fractions. These include mulitple myeloma, and associated conditions, nephrosis, hepatitis, collagen and gastrointestinal diseases.

Paraproteïnen zijn abnormale eiwitten in het bloed die in het eiwitspectrum te zien zijn als een extra piekje naast de normale pieken (albumine, alpha-1, alpha-2, beta en gamma globuline).

Barend van Zadelhoff
Local time: 07:42
Specializes in field
Native speaker of: Native in DutchDutch
PRO pts in category: 289

Peer comments on this answer (and responses from the answerer)
agree  Kitty Brussaard
2 days 23 hrs
  -> Dank je, Kitty.
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