03:47 Feb 13, 2018
This question was closed without grading. Reason: No acceptable answer

English to French translations [PRO]
Medical - Medical (general)
English term or phrase: jump-to-reference

Quelqu'un connait-il la traduction de cette expression ?

Contexte : "Missing data will be imputed using a reference based multiple imputation with a ***jump-to-reference*** approach or a standard multiple imputation depending on the reasons of withdrawal".

Merci d'avance pour vos lumières.

Local time: 04:37

Summary of answers provided
4appel à la référence ou appel de bas de page
Summary of reference entries provided
Specifying the imputation method



5 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
appel à la référence ou appel de bas de page

Notes de bas de page et autres références - Manuel de rédaction et d ...

S'il est nécessaire de citer à nouveau une référence pour garantir la clarté du texte, il convient de réutiliser l'appel de note sans répéter la note de bas de page, .... de bas de page s'appliquant à la même source se trouvent très éloignées les unes des autres, il convient d'inclure un renvoi à la note de bas de page originale.

Local time: 04:37
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 5010
Notes to answerer
Asker: Merci pour la proposition, mais effectivement, je ne crois pas que ça ait quelque chose à voir avec les notes de bas de page.

Peer comments on this answer (and responses from the answerer)
agree  marewa
2 hrs
  -> Thank you.

disagree  Daryo: this is about filing missing data => I don't think there is any "footnote" in this story .... // your examples are totally out of context - they have NOTHING to do with this ST.
5 hrs
  -> You disagree with half of the answer than. And I disagree with you. Appel à la référence is not necessarily a footnote.
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Reference comments

2 days 11 hrs
Reference: Specifying the imputation method

Reference information:
Specifying the imputation method - 1

Method ----- Name to specify in method()

Missing at random (MAR) --- vmar
Jump to reference --- j2r
Last mean carried forward --- lmcf
Copy increments in reference --- cir or ciir
Copy reference --- cr

https://www.stata.com/meeting/uk16/slides/cro_uk16.pdf page 26


“At a second advisory committee meeting held in September 2013 to discuss umeclidinium and vilanterol inhalation powder for the treatment of chronic obstructive pulmonary disease, differential dropout rates were observed in the phase 3 studies, with more placebo patients discontinuing due to lack of efficacy compared with those treated with the investigational drug. The statistical reviewer presented a sensitivity analysis using a ‘‘jump to reference’’ method that assumed any patient discontinuing treatment early would behave similarly to placebo patients post discontinuation, arguing that such an assumption was reasonable given the drug’s mechanism of action. The results of this and other analyses helped inform committee members about the impact of missing data on the primary results and also helped focus the discussion on the importance of not only how much data were missing but the reasons why and the way in which postdiscontinuation data were incorporated in the analysis”

The sensitivity analysis carried out by the applicant that we considered most reasonable was a Jump to Reference (J2R) multiple amputation approach. The assumptions of this approach in comparison to those of the MMRM are illustrated in this figure, which displays hypothetical data for patients dropping out after week eight.
Average FEV1 values over time are displayed by circles for patients on UMEC/VI and by triangles for patients on placebo. The red lines display observed data prior to dropout, illustrating an early treatment benefit. The green lines display the trends in pulmonary function after dropout that are assumed by the MMRM model, i.e., an assumption that the early benefit was maintained throughout the 24 weeks. The blue lines display the trends assumed by the Jump to Reference sensitivity analysis. This analysis, like the MMRM, assumes that placebo patients continued on the trend observed prior to dropout. However, unlike the MMRM, the Jump to Reference (J2R) approach multiply imputes missing data in patients on active treatment under the assumption that any treatment effect observed prior to dropout would have gone away by the time of the next visit.

the "reference" HERE is some group that is used as "reference group" for the purpose of filling missing data in trial results.

Note added at 2 days 12 hrs (2018-02-15 15:49:51 GMT)

as in:

a reference based multiple imputation with a jump-to-reference approach

a reference based = there is a "reference" that is used for filling missing data by some assumed values [= imputation] by "jumping to the reference" i.e. by looking what would be the value of the missing data in the reference group.

Note added at 2 days 12 hrs (2018-02-15 15:54:00 GMT)

Reference-based imputation (RBI) methods have been proposed as sensitivity analyses for longitudinal clinical trials with missing data. The RBI methods multiply impute the missing data in treatment group based on an imputation model built using data from the reference (control) group.


United Kingdom
Works in field
Native speaker of: Native in SerbianSerbian, Native in FrenchFrench
PRO pts in category: 63
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