completed vehicle

16:40 Mar 25, 2018
English to German translations [PRO]
Medical - Biology (-tech,-chem,micro-) / Biochemie, klinische Studien
English term or phrase: completed vehicle
Vehicle components include dimyrstoylphosphatidylcholine (DMPC) and Poloxamer in PBS
Completed vehicle components include dimyrstoylphosphatidylcholine (DMPC) and Poloxamer in PBS

ich verstehe hier nicht, wie "completed" gemeint ist.

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To evaluate the possible effect of the vehicle following the observed significant toxicity observed at 250 mg/kg (using vehicle containing 6% DMPC and 3% Poloxamer 188), additional groups of dogs were treated with the vehicle (6% DMPC and 3% Poloxamer), the “complete” vehicle (3% DMPC and 1.5% Poloxamer 188), or PBS/Poloxamer (a suitable formulation of DMPC in PBS could not be prepared).
Christine Matschke
Local time: 22:18

Summary of answers provided
3vollständiger Träger
Johannes Gleim

Discussion entries: 12



16 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
vollständiger Träger

Based on several comments and concerns expressed by agency participants with regard to the one completed vehicle-controlled study, the sponsor elected to conduct an additional vehicle-controlled study (No. 9104-CD271L-EV), which was initiated in March of 1991, and completed in August of 1991. The submission of the NDA was based on the November 7, 1990 meeting discussions and the completion of the subsequent clinical study.

We investigated the process of phospholipid vesicle fusion to a hydrophobic surface using electrochemical impedance spectroscopy (EIS) and atomic force microscopy (AFM). The kinetics of the fusion of dimyristoyl phosphatidylcholine (DMPC) vesicles to an octadecanethiol (ODT) self-assembled monolayer (SAM) was followed with EIS and found to be slower than previously reported observations by surface plasmon resonance. AFM images of the DMPC layer taken at various stages of completion show they are uniform with topography similar to that of the bare ODT SAM. The AFM was used in contact mode to scrape away a portion of a completed DMPC monolayer and the hole was stable for several hours.

Figure 6.3 BAM images of DMPC lipid film at 10 oC (A) and 40 oC (B); DMPC film containing half-loading of CNPs at 10 oC (C) and 40 oC (D); DMPC with full loading of CNPs at 10 oC (E) and 40 oC (F).
Figure 6.3 shows the lipid and the lipid with carbon film edges at 10 and 40 oC. Figure 6.3(A) and (B) show an incomplete DMPC-only film on a microscope slide at 10 and 40 oC, respectively.

Hier bedeutet "complete" offensichtlich "vollständig". Da ich mir im Kontext auch nichts anderes vorstellen kann, sollte man das ebenfalls verwenden, auch wenn die Beladung des Trägers geringer ist als ohne den Zusatz "complete".

vehicle [TECH.] die Trägerflüssigkeit Pl.: die Trägerflüssigkeiten
vehicle [TECH.] das Bindemittel [Farben und Lacke]

Bei Invertebraten gibt es neben Hämoglobin noch zwei weitere Sauerstoff-Träger, die als Hämocyanin und Hämerythrin bezeichnet werden.

Johannes Gleim
Local time: 22:18
Native speaker of: Native in GermanGerman
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