drug-like

Italian translation: composto farmacologico

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	drug-like compound
Italian translation:	composto farmacologico
Entered by:	Consuelo Marchioni

06:56 Jan 17, 2002

English to Italian translations [PRO]
Medical - Medical: Pharmaceuticals / Pharmacology

English term or phrase: drug-like

Distinguishing drug-like from non drug-like compounds.
Non ho altro contesto.

Ombretta Metelli KudoZ activity Questions: 39 (4 open) (1 without valid answers) Answers: 37
Local time: 16:29

distinguere i composti farmacologici da quelli non farmacologici

Explanation:
Oppure "di tipo farmacologico... di tipo non farmacologico".
Ovviamente questo è nel caso che si tratti di medicinali. Rimane da capire se si tratti invece di droghe nel senso di sostanze stupefacenti.
In ogni caso in Internet vi sono parecchi studi su questa distinzione tra composti farmacologici e non farmacologici, quindi ci sono buone probabilità che si tratti proprio di questo.

Selected response from:

Consuelo Marchioni
Italy
Local time: 16:29

Grading comment

Grazie mille dell'aiuto!
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +2

distinguere i composti farmacologici da quelli non farmacologici

Consuelo Marchioni

di tipo ... e non

Gilda Manara

vedi testo

Laura Gentili

composti dotati di caratteristiche farmacologiche e...

Giovanni Guarnieri MITI, MIL

Composti farmacologici e non

artemisia (X)

Answers

5 mins confidence:

di tipo ... e non

Explanation:
senza contesto drug è vago - può trattarsi di medicinale, o di stupefacente. (distinguere tra prodotti di tipo medicinale e non, o di tipo stupefacenti e non)

E' solo un'illazione

Gilda Manara
Italy
Local time: 16:29
Native speaker of:

Italian
PRO pts in category: 4

31 mins confidence:

peer agreement (net): +2

distinguere i composti farmacologici da quelli non farmacologici

Consuelo Marchioni
Italy
Local time: 16:29
Native speaker of:

Italian
PRO pts in category: 4

Grading comment

Grazie mille dell'aiuto!

43 mins confidence:

vedi testo

Explanation:
distinguere fra composti dotati di proprietà farmaceutiche e composti privi di tali proprietà.

Vedi ad esempio:
DRUG-SPACE
Early libraries designed on the basis of diversity did show increased rates of finding hits. However, inspection of the hits revealed that they tended to have undesirable properties as far as potential drug candidates are concerned. For example, they tended to have high molecular weights, to be too lipophilic, or to be insoluble. [28] In fact, it appears that maximizing diversity tends to bias the molecules in libraries away from desired ranges of these properties. Thus, the emphasis in library design has now shifted towards designing libraries that, while still diverse, contain compounds constrained to have drug-like physicochemical properties.
One way in which this is attempted is by applying preliminary filters to eliminate non-drug-like molecules from the reactant pools, for example, removing toxic and reactive groups; compounds with a large number of rotatable bonds; and compounds with high molecular weights. Some subset selection techniques now use additional properties within the design, for example, tailored D-optimal design [28] and the use of secondary properties to select compounds from cells in a partitioning procedure.
Recently, several more sophisticated approaches have been described that attempt to predict drug-likeness. [29-32] These methods have their basis in the fact that physicochemical properties are distributed differently in databases of drug-like molecules relative to non-drug-like molecules. [29] An example of this type of approach is the bioactivity profiles approach we have developed, [29] where a series of weights is derived that represent different values of physicochemical properties. The weights can be used to score and rank molecules according to their ability to discriminate between active and inactive compounds. Optimum weights are found using a GA. Figure 7 shows the results of applying drug-like weights to discriminate between molecules in the World Drugs Index, [33] which represents drug-like molecules, from molecules in SPRESI which represents non-drug-like molecules.

Laura Gentili
Italy
Local time: 16:29
Specializes in field
Native speaker of:

Italian
PRO pts in category: 193

2 hrs confidence:

composti dotati di caratteristiche farmacologiche e...

Explanation:
composti non dotati di caratteristiche farmacologiche.

vedi questi siti...
http://web.tiscali.it/biosalus/prod.htm

pharmacos.eudra.org/F2/register/an_pdf/human/166/h_166_an1_it.pdf
(qui si parla di composti curaro-simili, per esempio).

GG

Giovanni Guarnieri MITI, MIL
United Kingdom
Local time: 15:29
Works in field
Native speaker of:

Italian
PRO pts in category: 16

3 hrs confidence:

Composti farmacologici e non

Explanation:
i.e medicines (or medical candidates) and placebos or substances with no medical efficiency.

Reference: http://www.timtec.net/details/druglikecharacteristics.htm

artemisia (X)
Local time: 16:29
Native speaker of:

Italian

Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:

ProZ.com term search

Search millions of term translations