gene silencing

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12:54 Feb 9, 2010
English to Japanese translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics
English term or phrase: gene silencing
Definition from MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Example sentence(s):
  • Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms.
  • The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
  • In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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Definition from Wikipedia:
遺伝子サイレンシング(英:gene silencing、遺伝子抑制、ジーンサイレンシング)とは一般に、クロマチンへの後天的な修飾により遺伝子を制御する、いわゆるエピジェネティクス的遺伝子制御のことを示す。

Example sentence(s):
  • クローバー葉脈黄化ウイルスP1/HC-ProとタバコrgsCaMのショウジョウバエS2細胞における転写後遺伝子サイレンシング抑制能 (Suppression of Post-transcriptional Gene Silencing by Clover yellow vein virus P1/HC-Pro and Tobacco rgsCaM in Drosophila melanogaster S2 Cells) - CiNii (National Institute of Informatics  
  • ジェミニウイルスに対するRNAサイレンシング:宿主回復での転写後遺伝子サイレンシングと転写遺伝子サイレンシングの補完的作用 (RNA Silencing against Geminivirus: Complementary Action of Posttranscriptional Gene Silencing and Transcriptional Gene Silencing in Host Recovery) - J-Global  
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