gene silencing

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13:58 Feb 9, 2010
English to Latvian translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics
English term or phrase: gene silencing
Definition from MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Example sentence(s):
  • Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. biotech-info.net
  • The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
  • In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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Summary of translations provided
4 +1gēnu novājināšanās
Biruta MARKO
4Gēnu izslēgšana
Diana Fridrihsone


  

Translations offered


5 days   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
gēnu novājināšanās


Definition from own experience or research:
Jāapsver, kādā mērā ģenētiskā (ne)stabilitāte varētu izraisīt fenotipisko (ne)stabilitāti un bīstamību. Ģenētiskās modifikācijas nestabilitāte dažos gadījumos var izraisīt reversiju savvaļas fenotipā. Jāapsver citi gadījumi, piemēram:

- vai transgēnu auga līnijā, kas satur vairāk nekā vienu transgēnu, turpmākās nošķiršanas procesa rezultāts ir šo transgēnu sadalījums pēcnācējos, tad varētu rasties augi, kuros ir mazāk transgēnu, bet jauni fenotipi,
- vai novājinātiem mutantiem to nestabilitātes dēļ (konkrētas mutācijas struktūras dēļ) atgriežas virulence,
- vai transgēnu pavairošana izraisa gēnu novājināšanos,
- vai eksemplāru skaits ir pārāk liels,
- vai pārņemamo elementu atkārtotā insercijā jauni fenotipi rodas tāpēc, ka transgēnus inaktivē ar mobilu ģenētisko elementu inserciju,
- vai transgēnu izpausmes līmenis ir nozīmīgs (piemēram, ļoti maza toksiskas vielas izpausme), un regulējošā(–o) elementa(–u) nestabilitāte var pastiprināt transgēnu izpausmi.

Example sentence(s):
Biruta MARKO
Local time: 21:29
Native speaker of: Native in LatvianLatvian

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Andra Tomase
4 days
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31 days   confidence: Answerer confidence 4/5Answerer confidence 4/5
Gēnu izslēgšana


Definition from http://kalme.daba.lv/grozs/MolekularasBi:
DNS tiek metilēta C bāze (C → 5-MeC) CpG sekvencēs , t.s. CpG saliņas, galvenokārt promoteru rajonos. Metilēšana izraisa tālākus šīs modifikācijas fiksācijas procesus, kas noved pie stabilas gēna slēgšanas un hromatīna struktūras maiņām.

Example sentence(s):
Diana Fridrihsone
Latvia
Local time: 23:29
Native speaker of: Native in LatvianLatvian
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