recovery of mutations

10:22 Nov 28, 2006 

Czy nie chodzi tutaj przypadkiem o mutację powrotną/rewersję? Opracowanie jest tłumaczone z hiszpańskiego;

Mutants with the characteristics described here have not been reported previously, in spite of various searches for mutants that resist the glucose or the galactose effects. In the case of glucose, mutant alleles of MTH1 have appeared in different screens, while in those used to search for galactose resistance, mutations affecting either GAL2 or GAL4 have been found. These results indicate that an interference with the glucose signal, which involves the glucose sensors Snf3 and Rgt2, as well as Mth1, produces the strongest mutants, and that only a deletion of the MTH1 gene allows >>>recovery of mutations in other genes. It is noteworthy, however, that the mutations described in this work acted even in a MTH1 wild-type background.