observational data support switching

Polish translation: dane z badań obserwacyjnych wskazują na zmianę/alternatywny wybór

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:observational data support switching
Polish translation:dane z badań obserwacyjnych wskazują na zmianę/alternatywny wybór
Entered by: Frank Szmulowicz, Ph. D.

15:34 Jul 14, 2017
English to Polish translations [PRO]
Medical - Medical (general) / PsA - GRAPPA recommendations
English term or phrase: observational data support switching
Treatment algorithms for DMARD failure:

observational data support switching if failing a biologic
Barbara S21
Poland
dane z badań obserwacyjnych wskazują na zmianę/alternatywny wybór
Explanation:
Support (wskazują na, potwierdzają wniosek o). Switching refers to a change between alternatives - zalecają alternatywę (alternatywny zabieg, lek, etc.) - depending on the context.

--------------------------------------------------
Note added at 1 hr (2017-07-14 17:16:40 GMT)
--------------------------------------------------

4.6. Switching to an alternative class of biologics. . . . . . . . . . . . . . . . . . . 578
4.6.1. Rituximab. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 578
4.6.2. Abatacept . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579
4.6.3. Tocilizumab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579
4.5. Switch to another TNF-α blocker
Until the introduction of biologics with novel mechanisms of
action, switching between infliximab, etanercept and, later, adalimumab
after failure of a previous anti-TNF-α agent was a common
practice.


Strategies after failure of first anti-TNF-α agent due to inefficacy
include optimization of the concomitant methotrexate/DMARDs,
optimization of the infliximab or adalimumab dosing regimen or
switching to an alternative biologic agent.

have shown that switching to a second TNF-α
antagonist may be beneficial after the first has been discontinued, in
spite of the reason for discontinuation

] Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ, British Society for
Rheumatology Biologics Register. Outcomes after switching from one anti-tumor
necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in
patients with rheumatoid arthritiis

.
In summary, observational data support switching between TNF-α
inhibitors,
while a RCT has established the effectiveness of golimumab
after failure of a previous anti-TNF-α agent.


http://www.ans.gov.br/images/stories/Legislacao/camara_tecni...
Selected response from:

Frank Szmulowicz, Ph. D.
United States
Local time: 05:31
Grading comment
Dziękuję, pięknie Pan to ujął
4 KudoZ points were awarded for this answer



Summary of answers provided
2 +2dane z badań obserwacyjnych wskazują na zmianę/alternatywny wybór
Frank Szmulowicz, Ph. D.


  

Answers


1 hr   confidence: Answerer confidence 2/5Answerer confidence 2/5 peer agreement (net): +2
dane z badań obserwacyjnych wskazują na zmianę/alternatywny wybór


Explanation:
Support (wskazują na, potwierdzają wniosek o). Switching refers to a change between alternatives - zalecają alternatywę (alternatywny zabieg, lek, etc.) - depending on the context.

--------------------------------------------------
Note added at 1 hr (2017-07-14 17:16:40 GMT)
--------------------------------------------------

4.6. Switching to an alternative class of biologics. . . . . . . . . . . . . . . . . . . 578
4.6.1. Rituximab. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 578
4.6.2. Abatacept . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579
4.6.3. Tocilizumab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579
4.5. Switch to another TNF-α blocker
Until the introduction of biologics with novel mechanisms of
action, switching between infliximab, etanercept and, later, adalimumab
after failure of a previous anti-TNF-α agent was a common
practice.


Strategies after failure of first anti-TNF-α agent due to inefficacy
include optimization of the concomitant methotrexate/DMARDs,
optimization of the infliximab or adalimumab dosing regimen or
switching to an alternative biologic agent.

have shown that switching to a second TNF-α
antagonist may be beneficial after the first has been discontinued, in
spite of the reason for discontinuation

] Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ, British Society for
Rheumatology Biologics Register. Outcomes after switching from one anti-tumor
necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in
patients with rheumatoid arthritiis

.
In summary, observational data support switching between TNF-α
inhibitors,
while a RCT has established the effectiveness of golimumab
after failure of a previous anti-TNF-α agent.


http://www.ans.gov.br/images/stories/Legislacao/camara_tecni...

Frank Szmulowicz, Ph. D.
United States
Local time: 05:31
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 1891
Grading comment
Dziękuję, pięknie Pan to ujął

Peer comments on this answer (and responses from the answerer)
agree  Marcin Pustkowski: Lepiej bym tego nie ujął.
6 mins
  -> Coming from you, Marcin, this is high praise indeed. Muchas gracias, señor doctor.

agree  Jakub Kościelniak: Frank, trafienie w 10! Pozdrawiam :-)
3 hrs
  -> Dziękuję Kubo. Pozdrawiam wzajemnie.
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