Decreased IL2 receptor gamma chain

14:11 Jan 10, 2018
This question was closed without grading. Reason: No acceptable answer

English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-) / генетика
English term or phrase: Decreased IL2 receptor gamma chain
A genetically modified mouse according to aspects of the present invention has an IL2 receptor gamma chain deficiency. The term “IL2 receptor gamma chain deficiency” refers to decreased IL2 receptor gamma chain. ***Decreased IL2 receptor gamma chain*** can be due to gene deletion or mutation. Decreased IL2 receptor gamma chain can be detected, for example, by detection of IL2 receptor gamma chain gene deletion or mutation and/or detection of decreased IL2 receptor gamma chain expression using well-known methods. In certain embodiments, the IL2 receptor gamma chain deficiency is a null mutation of the IL2 receptor gamma chain gene. In certain embodiments, the animal having IL2 receptor gamma chain deficiency is a homozygous mutant for the IL2 receptor gamma chain.

Спасибо!
Nitrogen
Local time: 18:27


Summary of answers provided
4недостаточность гена гамма цепи рецептора il2
Alexander Delaver


  

Answers


30 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
decreased il2 receptor gamma chain
недостаточность гена гамма цепи рецептора il2


Explanation:
Первое испытание, подтвердившее эффективность генной терапии, проводилось у папиентов, страдающих Х-сцепленным тяжелым комбинированным иммунодефицитом , обусловленным дефицитом гена гамма-цепи рецептора ИЛ-2 . Отсутсгвие антигенспецифического иммунитета у этих пациентов было обусловлено отсутствием Т-клеток.


    Reference: http://humbio.ru/humbio/ped2pdd/000aa9a0.htm#0005ca12.htm
Alexander Delaver
Russian Federation
Local time: 19:27
Works in field
Native speaker of: Russian

Peer comments on this answer (and responses from the answerer)
neutral  Igor Andreev: продукта гена, в гене мутация или делеция, результатом чего является сниженая экспрессия или белок с укороченной последовательностью см. https://tinyurl.com/y7a4cxzk . Ценю humbio, но тут они загнули
6 hrs
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