single stage design
Russian translation: план испытания с проверкой статистической гипотезы в одну стадию
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| 16:24 Nov 28, 2006 |
| English to Russian translations [PRO] Medical - Mathematics & Statistics / статистический анализ | |||||
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|  Selected response from: mas63 Russian Federation Local time: 20:14 | ||||
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| 4 +1 | план испытания с проверкой статистической гипотезы в одну стадию |
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| 3 | одноэтапная процедура проверка (статистической) гипотезы |
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Answers
32 mins confidence: 
одноэтапная процедура проверка (статистической) гипотезы Explanation: .. -------------------------------------------------- Note added at 33 mins (2006-11-28 16:57:43 GMT) -------------------------------------------------- проверкИ |
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43 mins confidence: peer agreement (net): +1
peer agreement (net): +1план испытания с проверкой статистической гипотезы в одну стадию Explanation: Очевидно, Вы переводите текст по клиническим испытаниям. Фразу придется перефразировать с учетом следующего: HO - это нулевая гипотеза, согласно которой клинический ответ наблюдается у менее чем 30% пациентов из группы, H1 — это альтернативная гипотеза, согласно которой клинический ответ наблюдается у более чем 50% пациентов из группы. Группа — это группа пациентов, которой проводят комбинированное лечение. Significance level — уровень достоверности, с которым проверяются обе гипотезы. При этом обе гипотезы проверяются в одну стадию (или этап), т.е. на одной и той же группе пациентов. Пример: Many different designs have been proposed and used for Phase II clinical trials. The majority of these are based on frequentist statistical approaches. Bayesian methods provide an alternative to frequentist approaches, allowing for the incorporation of relevant prior information and the presentation of the trial results in a manner which some feel is more intuitive and helpful. In this article, we discuss two variants of a Bayesian design for Phase II clinical trials.(1) The design determines the overall sample size on the basis of achieving a minimum posterior probability of exceeding the target response rate value, should the trial data really suggest a positive outcome. We give sample size tables and cutoff values for the design. We also discuss how the design can be used in practice, using an example involving the treatment of metastatic nasopharyngeal cancer. Much of this article has been reproduced and adapted from Tan, S.B.; Machin, D., Bayesian two-stage designs for phase II clinical trials. Stat. Med. 2002, 21(14): 19912012. Permission has been obtained from John Wiley & Sons Inc. Reference: http://www.dekker.com/sdek/abstract~content=a713488696~db=en... |
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