Word of the day: intussusceptive angiogenesis

Russian translation: Инвагинирующий (впячивающий) тип ангиогенеза

03:29 Jun 1, 2020
English to Russian translations [PRO]
Medical - Medical (general) / blood vessels
English term or phrase: Word of the day: intussusceptive angiogenesis
Intussusceptive angiogenesis also known as splitting angiogenesis, is a type of angiogenesis, the process whereby a new blood vessel is created. By intussusception a new blood vessel is created by splitting of an existing blood vessel in two[1]. Intussusception occurs in normal development as well as in pathologic conditions involving wound healing[2], tissue regeneration, inflammation as colitis[3][4] or myocarditis[5] , lung fibrosis[6], and tumors[7][8] amongst others.

Intussusception was first observed in neonatal rats. In this type of vessel formation, the capillary wall extends into the lumen to split a single vessel in two. There are four phases of intussusceptive angiogenesis. First, the two opposing capillary walls establish a zone of contact. Second, the endothelial cell junctions are reorganized and the vessel bilayer is perforated to allow growth factors and cells to penetrate into the lumen. Third, a core is formed between the two new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an extracellular matrix for growth of the vessel lumen. Finally, the core is fleshed out with no alterations to the basic structure. Intussusception is important because it is a reorganization of existing cells. It allows a vast increase in the number of capillaries without a corresponding increase in the number of endothelial cells. This is especially important in embryonic development as there are not enough resources to create a rich microvasculature with new cells every time a new vessel develops.
Artyom Timeyev
Russian Federation
Local time: 20:32
Russian translation:Инвагинирующий (впячивающий) тип ангиогенеза
Explanation:
Инвагинирующий (впячивающий) тип ангиогенеза (образование сосудов путем инвагинации (впячивания))

http://naukarus.com/mehanizmy-i-faktory-angiogeneza
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Nadezhda Wenzel
Russian Federation
Local time: 19:32
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Summary of answers provided
3Инвагинирующий (впячивающий) тип ангиогенеза
Nadezhda Wenzel
Summary of reference entries provided
see
liz askew
интуссусцептивный ангиогенез
Nataliia Gorina

Discussion entries: 1





  

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2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
word of the day: intussusceptive angiogenesis
Инвагинирующий (впячивающий) тип ангиогенеза


Explanation:
Инвагинирующий (впячивающий) тип ангиогенеза (образование сосудов путем инвагинации (впячивания))

http://naukarus.com/mehanizmy-i-faktory-angiogeneza

Nadezhda Wenzel
Russian Federation
Local time: 19:32
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 16
Grading comment
Спасибо!
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Reference comments


4 hrs
Reference: see

Reference information:
Vasa venarum of the saphenous veins from the patients with ...anatomy.elpub.ru › article › download
PDFTranslate this page
In the adventitia and the media sprouting and non-sprouting angiogenesis were observed. ... почкования, «sprouting», так инвагинационный «non-sprouting» ангиогенез. Выводы. В ... Intussusceptive angiogenesis is an in- travascular ...

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Note added at 4 hrs (2020-06-01 08:17:40 GMT)
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file:///C:/Users/ken/Downloads/1077-2412-1-SM.pdf

ng in CD34-positive cells.
Results. Vasa venarum of the examined segments of human great saphenous veins were found both in the
adventitia and the tunica media. In case of the traumatic injury of the lower limb the adventitial vasa venarum
were 4.5 times more numerous (299 vessels/mm2) than those of great saphenous vein media (64 vessels/mm2). In
case of associated metabolic disorders we found increased number of vasa venarum of saphenous vein media,
247±109 vessels/mm2 and 253±51 vessels/mm2, respectively. However, the adventitial microvessel density was
lower in case of atherosclerosis (151±23 vessels/mm2) and associated diabetes mellitus (125±3 vessels/mm2). The
endothelial cell proliferation index was between 20% and 25% in saphenous vein from the patient with the traumatic injury. Moreover, the proliferation index was higher, ranged between 25% and 30%, in saphenous vein from
the patients with metabolic disorders. In the adventitia and the media sprouting and non-sprouting angiogenesis
were observed.

Результаты. В исследованных фрагментах больших подкожных вен человека, vasa venarum были
обнаружены в наружной и средней оболочках. При травматическом повреждении нижней конечности
Журнал анатомии и гистопатологии. 2020; 9(1) ◊ Journal of Anatomy and Histopathology. 2020; 9(1)
10
адвентициальные vasa venarum были в 4.5 раза многочисленнее (299 сосудов/мм2), чем в средней оболочке больших подкожных вен (64 сосуда/мм2). В случае сопутствующих метаболических нарушений было
обнаружено увеличение количества vasa venarum в средней оболочке подкожной вены, 247±109 сосудов/мм2 и 253±51 сосуд/мм2 соответственно. Однако, при атеросклерозе (151±23 сосуда/мм2) и ассоциированном сахарном диабете (125±3 сосуда/мм2) плотность адвентициальных микрососудов была ниже чем в
средней оболочке. Пролиферативный индекс эндотелиальных клеток в подкожной вене у пациента с
травматическими повреждениями составлял 20%–25%, в то время как у пациентов с нарушениями обмена
веществ был выше в диапазоне от 25% до 30%. В адвентиции и медии наблюдались как ангиогенез путем
почкования, «sprouting», так инвагинационный «non-sprouting» ангиогенез.

liz askew
United Kingdom
Specializes in field
Native speaker of: Native in EnglishEnglish
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10 hrs
Reference: интуссусцептивный ангиогенез

Reference information:
Описание и иллюстрация из книги "Онтогенез. От клетки до человека":
Интуссусцептивное ветвление: (а) три стадии интуссусцептивного ангиогенеза... Впячивания верхней и нижней стенок сосуда приводят к образованию опорного столбика, который разрастается вдоль оси сосуда, пока тот не делится на два
https://litresp.com/chitat/ru/Д/dejvis-dzhejmi/ontogenez-ot-...

Nataliia Gorina
Ukraine
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 113
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