first-uterine-pass effect

Russian translation: "эффект первого прохождения через матку"

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:first-uterine-pass effect
Russian translation:"эффект первого прохождения через матку"
Entered by: Stanislav Korobov

10:25 Nov 4, 2013
English to Russian translations [PRO]
Science - Medical: Pharmaceuticals / Фармакокинетика
English term or phrase: first-uterine-pass effect
Vaginal drug delivery is a potential route for therapy via topical action or systemic absorption as well as uterine targeting of active pharmaceutical ingredients. It offers advantages such as:
• large surface area
• avoiding hepatic first-pass effect, which may result in significant enhancement of bioavailability or reduction in dose strength or side-effect profile
• dense network of blood vessels
• high permeability even for large molecular weight drugs such as peptides and proteins
• low systemic drug exposure (namely in the case of products used for local conditions)
• low enzymatic activity and the possibility of preferential transfer of absorbed drugs to the uterus (referred to as the “first-uterine-pass effect”)
• ease of removal in case of necessity
Yuriy_B
Ukraine
Local time: 10:00
"эффект первого прохождения через матку"
Explanation:


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Note added at 23 mins (2013-11-04 10:49:05 GMT)
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Лучше в кавычках... Как вот здесь http://healyourselfathome.com/SUPPORTING_INFORMATION/CELL_ME... на английском, например:

“First Uterine Pass Effect” - The vaginal route is a better choice if the uterus /endometrium is the target area - PROGESTERONE has a direct impact on the uterus before entering circulation (the so-called first uterine pass effect).

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Note added at 25 mins (2013-11-04 10:51:33 GMT)
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Т.е. речь идёт, по существу, о местном воздействии на эндометрий, до попадания препарата в кровоток. И, соответственно, до прохождения через печень...
Selected response from:

Stanislav Korobov
Ukraine
Local time: 10:00
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4"эффект первого прохождения через матку"
Stanislav Korobov


  

Answers


18 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
"эффект первого прохождения через матку"


Explanation:


--------------------------------------------------
Note added at 23 mins (2013-11-04 10:49:05 GMT)
--------------------------------------------------

Лучше в кавычках... Как вот здесь http://healyourselfathome.com/SUPPORTING_INFORMATION/CELL_ME... на английском, например:

“First Uterine Pass Effect” - The vaginal route is a better choice if the uterus /endometrium is the target area - PROGESTERONE has a direct impact on the uterus before entering circulation (the so-called first uterine pass effect).

--------------------------------------------------
Note added at 25 mins (2013-11-04 10:51:33 GMT)
--------------------------------------------------

Т.е. речь идёт, по существу, о местном воздействии на эндометрий, до попадания препарата в кровоток. И, соответственно, до прохождения через печень...

Stanislav Korobov
Ukraine
Local time: 10:00
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 1094
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