BTK Occupancy Sample

Russian translation: образец для анализа занятости участков связывания ВТК (тирозинкиазы Брутона)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:BTK Occupancy Sample
Russian translation:образец для анализа занятости участков связывания ВТК (тирозинкиазы Брутона)
Entered by: Margarita Vidkovskaia

11:39 Feb 16, 2017
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals / Clinical Protocol, SCHEDULE OF TESTING
English term or phrase: BTK Occupancy Sample
SPECIMEN &/OR RESULT MANAGEMENT
(Contracted by Sponsor)
PK Primary Sample
PK Back up Sample
Genotypingm
Gene Expressionq
***BTK Occupancy Sample***
Margarita Vidkovskaia
Russian Federation
Local time: 00:15
образец для анализа занятости участков связывания ВТК
Explanation:
ВТК - тирозинкиназа Брутона
Selected response from:

Natalie
Poland
Local time: 23:15
Grading comment
Большое спасибо, Натали и Олег!
4 KudoZ points were awarded for this answer



Summary of answers provided
4образец для анализа занятости участков связывания ВТК
Natalie
Summary of reference entries provided
BTK = Bruton's tyrosine kinase
Oleg Lozinskiy

  

Answers


11 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
btk occupancy sample
образец для анализа занятости участков связывания ВТК


Explanation:
ВТК - тирозинкиназа Брутона

Natalie
Poland
Local time: 23:15
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 10343
Grading comment
Большое спасибо, Натали и Олег!
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Reference comments


15 mins
Reference: BTK = Bruton's tyrosine kinase

Reference information:
Bruton’s tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signaling downstream of a number of receptors.
...
BTK occupancy assay

Primary AML cells and U937 were treated with increasing concentrations of ibrutinib (0.3-1000 nM) for 1 hour. Cells were then washed in phosphate-buffered saline and stored at −80°C until a BTK occupancy assay was performed as described.
...
First we established the level of occupancy of the BTK active site by ibrutinib in AML cells. To do this, we treated primary AML sample #22 and AML cell line U937 with increasing concentrations of ibrutinib (3-1000 nM) for 1 hour.
http://www.bloodjournal.org/content/123/8/1229?sso-checked=t...

Oleg Lozinskiy
Russian Federation
Native speaker of: Native in RussianRussian
PRO pts in category: 179
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