tubular/papilla effects

Russian translation: [патологические] изменения почечных канальцев/сосочков

18:22 Feb 5, 2018
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: tubular/papilla effects
Toxicity findings appeared to correlate well with systemic exposure observed following administration of the three different continuous intravenous infusion regimens.

The 12.5 mg/kg/day 24-hour continuous regimen, with associated mean Day 1 AUC(0-24) of 8389 ng•h/mL, caused the most noticeable decreases in erythrocytes, WBC, lymphocytes platelets, protein, blood urea nitrogen (BUN), creatinine, sorbitol dehydrogenase (SDH) and lipase parameters when compared to the hematology effects in the 24-hours-on/24-hours-off regimen (decreased erythrocytes, WBC and protein) where the associated mean Day 1 AUC(0-24) was 8688 ng•h/mL, and the 12-hours-on/12-hours-off regimen (erythrocyte decreases), where the associated mean AUC(0-24) was 3300 ng•h/mL.

Similarly, histological changes in the 24-hours continuous regimen were typically most severe in the adrenals (hemorrhage, necrosis, sinusoidal dilatation), bone marrow (depletion), heart (minimal necrosis), bone joint (growth plate thickening), kidneys (glomerulopathy, tubular/papilla effects), pancreas (acinar atrophy, necrosis), and thymus (atrophy).

Fewer organ systems were affected in the 24-hours-on/24-hours-off regimen, (adrenals, bone marrow, bone joint and lung), compared to those of the 24-hour continuous dosing group, and only the lungs and bone joint were affected in the 12-hours-on/12-hours-off regimen.
Maxim Polukhin
Local time: 02:19
Russian translation:[патологические] изменения почечных канальцев/сосочков
Explanation:
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Note added at 15 mins (2018-02-05 18:38:01 GMT)
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Подобным образом, при применении в непрерывном 24-часовом режиме, наиболее тяжелые гистологические изменения, как правило, наблюдались в надпочечниках (...), костном мозге (...), сердце (...), ....почках (гломерулопатия, изменения почечных канальцев и сосочков), поджелудочной железе (атрофия ацинарных клеток, некроз) и тимусе (атрофия).

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Note added at 1 hr (2018-02-05 20:03:23 GMT)
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наиболее выраженные (а не тяжелые) гистологические изменения
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Margarita Vidkovskaia
Russian Federation
Local time: 02:19
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Summary of answers provided
4[патологические] изменения почечных канальцев/сосочков
Margarita Vidkovskaia


  

Answers


4 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
[патологические] изменения почечных канальцев/сосочков


Explanation:
.

--------------------------------------------------
Note added at 15 mins (2018-02-05 18:38:01 GMT)
--------------------------------------------------

Подобным образом, при применении в непрерывном 24-часовом режиме, наиболее тяжелые гистологические изменения, как правило, наблюдались в надпочечниках (...), костном мозге (...), сердце (...), ....почках (гломерулопатия, изменения почечных канальцев и сосочков), поджелудочной железе (атрофия ацинарных клеток, некроз) и тимусе (атрофия).

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Note added at 1 hr (2018-02-05 20:03:23 GMT)
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наиболее выраженные (а не тяжелые) гистологические изменения

Margarita Vidkovskaia
Russian Federation
Local time: 02:19
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 757
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