T-cell/histiocyte rich large B-cell lymphoma

Russian translation: В-клеточная крупноклеточная лимфома, богатая Т-клетками/гистиоцитами

09:01 Nov 15, 2018
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals / Position on extrapolation
English term or phrase: T-cell/histiocyte rich large B-cell lymphoma
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Mantle cell lymphoma
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•T-cell/histiocyte rich large B-cell lymphoma
•DLBCL associated with chronic inflammation
•Epstein-Barr virus (EBV)+ DLBCL of the eldery
T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Julia Berezina
Local time: 06:48
Russian translation:В-клеточная крупноклеточная лимфома, богатая Т-клетками/гистиоцитами
Explanation:
Вот описание:

The original term of “T-cell-rich B-cell lymphoma” was introduced to describe a variety of B-cell lymphomas with a prominent T-cell reaction mimicking T-cell lymphoma.1 The presence of less than 10% (sometime as low as 1%) of usually large, atypical B cells in a background rich in T cells was the unifying feature of the diagnosis. B-cell lymphomas with a prominent T-cell reaction ranged from low-grade lymphomas such as chronic lymphocytic leukemia1 and follicular lymphoma to diffuse large B-cell lymphomas.1–3 These were important diagnostic contributions that emphasized the utility of immunohistochemistry, and in some cases molecular studies,4 for the correct identification of the neoplastic population in an unusually rich reactive milieu. However, at this stage the emphasis was on the distinction from peripheral T-cell lymphoma, and not on the delineation of a new disease entity. Indeed, it appeared that this host reaction could be associated with a variety of B-cell neoplasms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833061/

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Note added at 1 hr (2018-11-15 10:09:43 GMT)
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или "В-крупноклеточная"

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Note added at 1 hr (2018-11-15 10:12:03 GMT)
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Это по той же ссылке:

Since the first recognition of certain large B-cell lymphomas in which the tumor cell content was dramatically outnumbered by reactive T cells or less often histiocytes, this descriptive term and related terms have been used to characterize a variety of lymphoma subtypes, and different studies have varied in the criteria used for this designation.

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Note added at 1 hr (2018-11-15 10:17:11 GMT)
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T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin’s lymphoma characterized by malignant B cells with reactive T lymphocytes.

https://www.hindawi.com/journals/crionm/2017/6428461/

T-cell/histiocyte-rich large B cell lymphoma (THRLBCL) is a distinct entity of aggressive lymphoma, recognized by the WHO classification as a separate entity (2008), in which few scattered neoplastic cells (usually <5%) are surrounded by reactive T-lymphocytes and histiocytes. THRLBCL shares several morphological and immunophenotypic similarities with nodular lymphocyte-predominant Hodgkin's lymphoma (Pittaluga et al., 2010). These two entities may share initial transforming events that occur at germinal center B cell, followed by early divergence in the evolution of the neoplastic process (Franke et al., 2002).

http://atlasgeneticsoncology.org/Anomalies/TrichLargBCLID207...

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Note added at 1 hr (2018-11-15 10:18:21 GMT)
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Т-лимфоциты здесь реактивные, то есть мигрируют в зону очага.
Selected response from:

Evgeni Kushch
Ukraine
Local time: 06:48
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1В-клеточная крупноклеточная лимфома, богатая Т-клетками/гистиоцитами
Evgeni Kushch


  

Answers


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
t-cell/histiocyte rich large b-cell lymphoma
В-клеточная крупноклеточная лимфома, богатая Т-клетками/гистиоцитами


Explanation:
Вот описание:

The original term of “T-cell-rich B-cell lymphoma” was introduced to describe a variety of B-cell lymphomas with a prominent T-cell reaction mimicking T-cell lymphoma.1 The presence of less than 10% (sometime as low as 1%) of usually large, atypical B cells in a background rich in T cells was the unifying feature of the diagnosis. B-cell lymphomas with a prominent T-cell reaction ranged from low-grade lymphomas such as chronic lymphocytic leukemia1 and follicular lymphoma to diffuse large B-cell lymphomas.1–3 These were important diagnostic contributions that emphasized the utility of immunohistochemistry, and in some cases molecular studies,4 for the correct identification of the neoplastic population in an unusually rich reactive milieu. However, at this stage the emphasis was on the distinction from peripheral T-cell lymphoma, and not on the delineation of a new disease entity. Indeed, it appeared that this host reaction could be associated with a variety of B-cell neoplasms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833061/

--------------------------------------------------
Note added at 1 hr (2018-11-15 10:09:43 GMT)
--------------------------------------------------

или "В-крупноклеточная"

--------------------------------------------------
Note added at 1 hr (2018-11-15 10:12:03 GMT)
--------------------------------------------------

Это по той же ссылке:

Since the first recognition of certain large B-cell lymphomas in which the tumor cell content was dramatically outnumbered by reactive T cells or less often histiocytes, this descriptive term and related terms have been used to characterize a variety of lymphoma subtypes, and different studies have varied in the criteria used for this designation.

--------------------------------------------------
Note added at 1 hr (2018-11-15 10:17:11 GMT)
--------------------------------------------------

T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin’s lymphoma characterized by malignant B cells with reactive T lymphocytes.

https://www.hindawi.com/journals/crionm/2017/6428461/

T-cell/histiocyte-rich large B cell lymphoma (THRLBCL) is a distinct entity of aggressive lymphoma, recognized by the WHO classification as a separate entity (2008), in which few scattered neoplastic cells (usually <5%) are surrounded by reactive T-lymphocytes and histiocytes. THRLBCL shares several morphological and immunophenotypic similarities with nodular lymphocyte-predominant Hodgkin's lymphoma (Pittaluga et al., 2010). These two entities may share initial transforming events that occur at germinal center B cell, followed by early divergence in the evolution of the neoplastic process (Franke et al., 2002).

http://atlasgeneticsoncology.org/Anomalies/TrichLargBCLID207...

--------------------------------------------------
Note added at 1 hr (2018-11-15 10:18:21 GMT)
--------------------------------------------------

Т-лимфоциты здесь реактивные, то есть мигрируют в зону очага.

Evgeni Kushch
Ukraine
Local time: 06:48
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 1280
2 corroborated select projects
in this pair and field What is ProZ.com Project History(SM)?

Peer comments on this answer (and responses from the answerer)
agree  Igor_2006: может быть, просто "В-крупноклеточная лимфома, богатая Т-клетками и/или гистиоцитами" (чтобы не повторяться с "клеточной") - убрал свой ответ, чтобы никого не путать.
38 mins
  -> Спасибо, Игорь!
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