deep in the TTR binding pocket

Russian translation: глубоко в TTR-связывающем кармане

08:59 Nov 25, 2019
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: deep in the TTR binding pocket
It has long been observed that individuals who inherit the T119M trans-suppressor mutation along with the highly penetrant, pathogenic V30M mutation either do not develop disease or develop disease at a much slower rate (Coelho 1993, Coelho 1996, Hammarström 2002, Berk 2013 ).
The T119M variant tetramer has been shown to dissociate into dimers and monomers 33-fold more slowly than the wild-type tetramer, and the structural basis for this observation has been explored through X-ray crystallography and kinetic studies.
The second line of evidence supporting AG10’s therapeutic potential comes from structural biology data that led to its structure-based drug design.
The super-stabilizing effect of the T119M amino acid substitution has been attributed to unique hydrogen bonds that form between adjacent serine residues at position 117 contributed by individual TTR monomers **deep in the TTR binding pocket**.
These serine residues are brought close enough together (
Maxim Polukhin
Local time: 16:58
Russian translation:глубоко в TTR-связывающем кармане
Explanation:
глубоко в транстиретин-связывающем кармане
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Natalie
Poland
Local time: 14:58
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4глубоко в TTR-связывающем кармане
Natalie


  

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38 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
deep in the ttr binding pocket
глубоко в TTR-связывающем кармане


Explanation:
глубоко в транстиретин-связывающем кармане

Natalie
Poland
Local time: 14:58
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 10549
Grading comment
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