longitudinal LMWT natural history data

Russian translation: данные теста с 6-минутной ходьбой в продольном исследовании с наблюдением ...

18:36 Apr 5, 2021

English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals

English term or phrase: longitudinal LMWT natural history data

In the current renewal the MAH has provided an update with reassurance that study 020 is ongoing and still blinded.
No efficacy data has been provided.
Therefore the entire discussion about the certainties and uncertainties regarding the beneficial effects of ataluren in the treatment of nmDMD patients remain the same.
Several lines of evidence support the clinical relevance of a 30-meter difference in 6MWT, including a report showing that a 30-meter change in 6MWD over 48 weeks can be considered a clinically meaningful change based on the patient/parent-reported quality of life measures in DMD patients.
This is also supported by results of **longitudinal LMWT natural history data** in DMD, indicating that each 30-meter decrease in baseline 6MWD predicts increasing risk of loss of ambulation over the following 2 years.
Ability to climb and descend a short grouping of stairs, ability to run in short bursts, or to walk a short distance unaided, e.g. to a bathroom, reflect the typical activities important in the lives of DMD patients.
Importantly, recent data indicated that timed function tests evaluating these abilities are , similarly to 6MWT, predictive of the time for a patient to become non-ambulatory.
Falls commonly lead to fractures in DMD patients and the injuries sustained may accelerate loss of ambulation.

Maxim Polukhin KudoZ activity Questions: 8838 (2 open) (1 without valid answers) (739 closed without grading) Answers: 43
Local time: 10:02

Russian translation:данные теста с 6-минутной ходьбой в продольном исследовании с наблюдением ...

Explanation:
...за пациентами в естественных условиях

В исходном тексте опечатка: L вместо 6, судя по контексту (6MWT):
http://humbio.ru/humbio/ftiziatria/000f7fca.htm
Тест с 6-минутной ходьбой (6MWT)...

https://ichgcp.net/ru/clinical-trials-registry/NCT02864589
... Через 3 месяца мы будем наблюдать за пациентами в естественных условиях в течение 12 месяцев после окончания лечения

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Note added at 4 hrs (2021-04-05 22:57:45 GMT)
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https://www.sportmedicine.ru/evidence-based_medicine.php
...Проспективное (когортное, продольное) исследование — исследование, в котором выделенная когорта участников наблюдается в течение определенного времени.

Selected response from:

cherepanov
Ukraine
Local time: 10:02

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4 KudoZ points were awarded for this answer

Summary of answers provided

4 +1

данные теста с 6-минутной ходьбой в продольном исследовании с наблюдением ...

cherepanov

3 -1

накопление тиолов с низким молекулярным весом в организме в естественных условиях с течением времени

Oleg Lozinskiy

Answers

24 mins confidence:

peer agreement (net): -1

longitudinal lmwt natural history data накопление тиолов с низким молекулярным весом в организме в естественных условиях с течением времени

Explanation:

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Note added at 29 мин (2021-04-05 19:06:03 GMT)
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Либо "изменение концентрации" вместо "накопления".

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Note added at 36 мин (2021-04-05 19:13:16 GMT)
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Например:

У больных РМЖ с различными гистологическими типами (инфильтративно–протоковым и инфильтративно–дольковым, а также смешанным и редкими формами РМЖ) обнаруживается изменение концентрации тиолов в сыворотке крови.
https://www.google.ru/url?sa=t&rct=j&q=&esrc=s&source=web&cd...

Oleg Lozinskiy
Russian Federation
Local time: 10:02
Native speaker of:

Russian
PRO pts in category: 533

4 hrs confidence:

peer agreement (net): +1

longitudinal lmwt natural history data

данные теста с 6-минутной ходьбой в продольном исследовании с наблюдением ...

cherepanov
Ukraine
Local time: 10:02
Specializes in field
Native speaker of:

Russian
PRO pts in category: 1147

Grading comment

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