genome-wide expression profiling approach

Spanish translation: aproximación a la determinación de la expresión hologenómica/pangenómica

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English term or phrase:genome-wide expression profiling approach
Spanish translation:aproximación a la determinación de la expresión hologenómica/pangenómica
Entered by: Jorge Arteaga M.D.

17:27 May 4, 2016
English to Spanish translations [PRO]
Medical - Genetics
English term or phrase: genome-wide expression profiling approach
En un artículo titulado "Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines":

"Since the therapeutic immunosuppression of AZA and 6-MP is evident in the setting of chronic inflammatory diseases, but usually does not predispose to opportunistic infections, we reasoned that these drugs act by selectively affecting activated but not resting immune cells. To test this possibility, we developed an in vitro system of AZA-treated T lymphocytes that models closely the effects of AZA therapy on those cells in vivo. Using a **genome-wide expression profiling approach**, we evaluated the effects of AZA on the expression of genes in both resting and stimulated T lymphocytes. Our results have identified several immune and inflammation-related genes whose up-regulated expression is potently inhibited by thiopurines in activated but not resting T lymphocytes, suggesting potential novel immunosuppressive mechanisms of these drugs."

genome-wide indica "relación con todo el genoma o el ADN completo de un individuo" [Navarro] y se traduce "hologenómico" (Navarro) o "pangenómico" (Igea). Hasta los momentos he colocado "método de elaboración de perfiles de expresión pangenómica", pero no sé si está correcto.

Muchísimas gracias por adelantado
Yvonne Becker
Local time: 08:34
aproximación a la determinación de la expresión hologenómica/pangenómica
Explanation:
Your translation "método de elaboración de perfiles de expresión pangenómica" sounds good to me, but I believe here profiling refers to determining the expression and I like it better.

Saludos...
Selected response from:

Jorge Arteaga M.D.
United States
Local time: 07:34
Grading comment
Muchas gracias
4 KudoZ points were awarded for this answer



Summary of answers provided
4aproximación a la determinación de la expresión hologenómica/pangenómica
Jorge Arteaga M.D.


Discussion entries: 1





  

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25 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
aproximación a la determinación de la expresión hologenómica/pangenómica


Explanation:
Your translation "método de elaboración de perfiles de expresión pangenómica" sounds good to me, but I believe here profiling refers to determining the expression and I like it better.

Saludos...

Jorge Arteaga M.D.
United States
Local time: 07:34
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 8
Grading comment
Muchas gracias
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