solvent front mutation

Spanish translation: Mutación del frente del disolvente

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:solvent front mutation
Spanish translation:Mutación del frente del disolvente
Entered by: Marocas

05:03 Nov 12, 2019
English to Spanish translations [PRO]
Medical - Medical (general) / Genetics
English term or phrase: solvent front mutation
Contexto:

Sometimes cancers have a mutation in RET called a fusion that makes them dependent on this gene.
You are being offered this treatment plan because genetic testing performed on your lung cancer found a RET fusion, you were additionally found to have a **solvent front mutation**, and you were previously treated with XXXX.

Gracias de antemano.
Marocas
Venezuela
Local time: 08:37
Mutación del frente del disolvente
Explanation:
Solo he encontrado esto en espanol, que es la traducción literal:

Nuevos biomarcadores en el cáncer de pulmón ... - DocPlayer
https://docplayer.es › 139009923-Nuevos-biomarcadores-en-el-cancer-de-...
Proteína receptora con actividad tirosina cinasa d. ..... se produce en el frente del disolvente del dominio de la tirosina cinasa y es un parálogo de los genes ALK ...

El "solvent front" de una cinasa es la región de la misma expuesta a disolventes. Una "solvent front mutation" es una mutación en esta región":

Targeted Therapies for Lung Cancer
https://books.google.de › books - Diese Seite übersetzen
Ravi Salgia - 2019 - ‎Medical
Crystal structure analysis revealed that the G2032 residue sits at the solvent front of the kinase hinge (solvent-exposed region of the kinase). G2032R causes ...

A Surface of the Kinase Domain Critical for the ... - NCBI
https://www.ncbi.nlm.nih.gov › articles › PMC2719358
Diese Seite übersetzen
von C Huang - ‎2009 - ‎Zitiert von: 64 - ‎Ähnliche Artikel
13.04.2009 - All of these residues are solvent-exposed in crystal structures and, after mutation, retain the ability to bind ADP with affinities similar to wild type. ... There are several possible mechanisms for how the residues we identified might be involved in kinase activation.


Saludos
Selected response from:

Teresa Mozo
Local time: 13:37
Grading comment
¡Gracias!
3 KudoZ points were awarded for this answer



Summary of answers provided
3 +1Mutación del frente del disolvente
Teresa Mozo


  

Answers


2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
Mutación del frente del disolvente


Explanation:
Solo he encontrado esto en espanol, que es la traducción literal:

Nuevos biomarcadores en el cáncer de pulmón ... - DocPlayer
https://docplayer.es › 139009923-Nuevos-biomarcadores-en-el-cancer-de-...
Proteína receptora con actividad tirosina cinasa d. ..... se produce en el frente del disolvente del dominio de la tirosina cinasa y es un parálogo de los genes ALK ...

El "solvent front" de una cinasa es la región de la misma expuesta a disolventes. Una "solvent front mutation" es una mutación en esta región":

Targeted Therapies for Lung Cancer
https://books.google.de › books - Diese Seite übersetzen
Ravi Salgia - 2019 - ‎Medical
Crystal structure analysis revealed that the G2032 residue sits at the solvent front of the kinase hinge (solvent-exposed region of the kinase). G2032R causes ...

A Surface of the Kinase Domain Critical for the ... - NCBI
https://www.ncbi.nlm.nih.gov › articles › PMC2719358
Diese Seite übersetzen
von C Huang - ‎2009 - ‎Zitiert von: 64 - ‎Ähnliche Artikel
13.04.2009 - All of these residues are solvent-exposed in crystal structures and, after mutation, retain the ability to bind ADP with affinities similar to wild type. ... There are several possible mechanisms for how the residues we identified might be involved in kinase activation.


Saludos

Teresa Mozo
Local time: 13:37
Works in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 286
Grading comment
¡Gracias!

Peer comments on this answer (and responses from the answerer)
agree  Diego Rivera
19 hrs
  -> muchas gracias
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