upstream/downstream processes

05:30 Feb 3, 2013
This question was closed without grading. Reason: Answer found elsewhere

English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / Clinical Studies
English term or phrase: upstream/downstream processes
The manufacturing process of [xxxx] consists of upstream cell culture and downstream purification processes.
Cells used for production are free of contamination during the upstream process and allow high levels of safety and purity of the resulting [name of the drug] during the downstream process.
Local time: 11:36

Summary of answers provided
3 +2procesos de elaboración/ de transformación
Summary of reference entries provided

Discussion entries: 5



11 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
procesos de elaboración/ de transformación

Please see reference

United States
Local time: 08:36
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish
PRO pts in category: 67

Peer comments on this answer (and responses from the answerer)
agree  Mónica Algazi
1 hr
  -> Un abrazo!

agree  anademahomar
3 hrs
  -> Un abrazo Anita y gracias!

neutral  M. C. Filgueira: No usaría estos términos (¿derivados de una trad.?) para referirme a un proc. biotec. farmacéutico, debido al sentido del "transf." en biol. molec. y biotecnol. En esta frase "upstream" y "downstream" son pleonásmicos y pueden obviarse. Saludos cordiales.
9 hrs
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Reference comments

15 mins peer agreement (net): +4
Reference: Findings

Reference information:
El proceso íntegro de producción de un producto biotecnológico, de inicio a fin, suele conocerse como campaña y normalmente se divide en dos partes principales: elaboración (upstream) y transformación (downstream) .Los procesos de elaboración suponen la producción del producto proteico, con mayor frecuencia mediante la utilización de células (de microbios, insectos o mamíferos) que crecen en cultivo. Los procesos de transformación comprenden la recuperación, purificación, formulación y acondicionamiento del producto proteico.
Fase de elaboración (upstream)
La fase de elaboración comienza con las células que crean o diseñan los científicos para obtener el producto proteico [...]
Fase de transformación (downstream)
En la fase de transformación de la fabricación se aísla el producto proteico a partir de las células que lo produjeron.

United States
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish
PRO pts in category: 67

Peer comments on this reference comment (and responses from the reference poster)
agree  Mónica Algazi: ¿Y si lo escribes como respuesta, Lorena?
5 hrs
  -> Thank you, I have posted it as an answer :-) un abrazo
agree  Rafael Molina Pulgar
8 hrs
  -> Gracias Rafael
agree  Alistair Ian Spearing Ortiz: I concur with Mónica.
10 hrs
  -> Thank you, I have posted it as an answr, happy Sunday!
agree  anademahomar
15 hrs
  -> gracias and Happy Sunday!
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