tophus response, target tophus ETC

19:38 Aug 31, 2014
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / treatment of gout
English term or phrase: tophus response, target tophus ETC
I have written in capital letters where I need expertise suggestions. Thanks!

Efficacy Assessments of XYZ medication:


Proportion of subjects with a BEST TOPHUS RESPONSE on at least 1 TARGET TOPHUS of complete or partial resolution by Month 12



To investigate by a population analysis approach the influence of intrinsic factors (age, race, sex, body weight, renal function, concomitant medication use) ON ORAL CLEARANCE of "medication".
Taous Sawyer

Summary of reference entries provided
respuesta al tofo, objetivos del tofo, etc.
references to check
Joseph Tein
EU Clinical Trial register


Reference comments

2 hrs
Reference: respuesta al tofo, objetivos del tofo, etc.

Reference information:
tophus - definition - r...
Tophus response to therapy for each subject -
¿Qué es un tofo gotoso? - -...
la respuesta al medicamento -
Los objetivos del tratamiento son controlar el dolor y los ataques agudos y prevenir futuros episodios así como la formación de tofos y cálculos renales. -
iponatremia, deshidratación, etc -

Native speaker of: Native in PortuguesePortuguese
PRO pts in category: 8
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3 hrs
Reference: references to check

Reference information:
Hi Taous :) The "oral clearance" question has been asked and answered here before ... see the first link below.

To me, "aclaramiento oral" would work fine. I find it on a large enough number of web sites in a google search to make me trust it. Below is one example sentence I've found.

As to your other question (to answer before a moderator comes along and removes this) I think you'll find the exact translation on the site below, which my second link will take you to (go to section E.5.2.)

Note added at 3 hrs (2014-08-31 22:59:45 GMT)

Also found online:

"En pacientes tratados con inductores potentes del CYP3A4 (por ejemplo, la DFH, la carbamazepina y la ­rifampicina), aumentó el aclaramiento oral del ONDANSETRÓN y disminuyeron las concentraciones sanguíneas."

Example sentence(s):
  • En un estudio de dosis única, el aclaramiento oral (CL/F) disminuyó aproximadamente un 50 % en voluntarias con insuficiencia hepática moderada, comparado con las voluntarias con función hepática normal.

Joseph Tein
United States
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
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612 days
Reference: EU Clinical Trial register

Reference information:
I know I am like 2 years late, but you should check this website:

Specializes in field
Native speaker of: Native in SpanishSpanish
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