block-replace regimen

Spanish translation: Régimen Block-Replace / Régimen de bloqueo y reemplazo

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:block-replace regimen
Spanish translation:Régimen Block-Replace / Régimen de bloqueo y reemplazo
Entered by: Elena Sgarbo (X)

02:06 Dec 13, 2003
English to Spanish translations [PRO]
Medical
English term or phrase: block-replace regimen
hypertiroidism
cymbeline
Local time: 09:10
Régimen Block-Replace / Régimen de bloqueo y reemplazo
Explanation:
Hola cymbeline

"Block-Replace" es el nombre de un tratamiento para el hipertiroidismo que consiste en bloquear completamente la actividad de la glándula tiroides (gral.mente con carbimazol) y administrar terapia de reemplazo hormonal (con tiroxina), dado que la glándula está bloqueada y el pte. tendría, si no, hipotiroidismo.

"Block-Replace" se podría dejar sin traducir (no hay traducción "oficial", que yo sepa), o bien traducir como "bloqueo y reemplazo".

Suerte
Elena


Nineteen randomised trials involving 2233 participants were included. Overall the quality of trials as reported was poor; specifically in terms of allocation concealment, assessor blinding and loss to follow-up. Four trials examined the effect of duration of therapy on relapse rates of Graves' hyperthyroidism. In one trial using the Titration regimen, longer duration therapy (18 months) had significantly fewer relapses (37% vs 58%) than six month therapy (Odds ratio (OR) = 0.42, 95% confidence interval (CI) 0.18 to 0.96). In one quasi-randomised trial using the **Block-Replace regimen**, there was no significant difference between the six and 12 month (relapses rates 41% versus 35%) arms of the study. Extending the duration of therapy to over 18 months was not associated with improved relapse rates (Peto OR = 0.75, 95% CI 0.39 to 1.43). Ten trials examined the effect of **Block-Replace** versus Titration regime.....


Weetman AP, Pickerill AP, Watson P, Chatterjee VK, Edwards OM. Treatment of Graves' disease with the **block-replace regimen** of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse.
Q J Med. 1994 Jun;87(6):337-41.


Treatment of Graves' disease with the block-replace regimen of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse.

Weetman AP, Pickerill AP, Watson P, Chatterjee VK, Edwards OM.

Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, UK.

Antithyroid drugs are commonly used as first-line treatment for Graves' disease, but the optimum regimen for inducing remission remains unclear. We gave the **block-replace regimen** of carbimazole plus thyroxine to 100 patients for 6 or 12 months, to determine whether prolonged treatment is associated with fewer relapses....
Selected response from:

Elena Sgarbo (X)
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Gracias!
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Summary of answers provided
5Régimen Block-Replace / Régimen de bloqueo y reemplazo
Elena Sgarbo (X)


  

Answers


23 mins   confidence: Answerer confidence 5/5
Régimen Block-Replace / Régimen de bloqueo y reemplazo


Explanation:
Hola cymbeline

"Block-Replace" es el nombre de un tratamiento para el hipertiroidismo que consiste en bloquear completamente la actividad de la glándula tiroides (gral.mente con carbimazol) y administrar terapia de reemplazo hormonal (con tiroxina), dado que la glándula está bloqueada y el pte. tendría, si no, hipotiroidismo.

"Block-Replace" se podría dejar sin traducir (no hay traducción "oficial", que yo sepa), o bien traducir como "bloqueo y reemplazo".

Suerte
Elena


Nineteen randomised trials involving 2233 participants were included. Overall the quality of trials as reported was poor; specifically in terms of allocation concealment, assessor blinding and loss to follow-up. Four trials examined the effect of duration of therapy on relapse rates of Graves' hyperthyroidism. In one trial using the Titration regimen, longer duration therapy (18 months) had significantly fewer relapses (37% vs 58%) than six month therapy (Odds ratio (OR) = 0.42, 95% confidence interval (CI) 0.18 to 0.96). In one quasi-randomised trial using the **Block-Replace regimen**, there was no significant difference between the six and 12 month (relapses rates 41% versus 35%) arms of the study. Extending the duration of therapy to over 18 months was not associated with improved relapse rates (Peto OR = 0.75, 95% CI 0.39 to 1.43). Ten trials examined the effect of **Block-Replace** versus Titration regime.....


Weetman AP, Pickerill AP, Watson P, Chatterjee VK, Edwards OM. Treatment of Graves' disease with the **block-replace regimen** of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse.
Q J Med. 1994 Jun;87(6):337-41.


Treatment of Graves' disease with the block-replace regimen of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse.

Weetman AP, Pickerill AP, Watson P, Chatterjee VK, Edwards OM.

Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, UK.

Antithyroid drugs are commonly used as first-line treatment for Graves' disease, but the optimum regimen for inducing remission remains unclear. We gave the **block-replace regimen** of carbimazole plus thyroxine to 100 patients for 6 or 12 months, to determine whether prolonged treatment is associated with fewer relapses....



    Reference: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
Elena Sgarbo (X)
Native speaker of: Native in SpanishSpanish
PRO pts in pair: 3982
Grading comment
Gracias!
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